Edwards Lifesciences Corporation

Second Sight Medical Products, Inc.

Da-Yu Chang

Brian S Conklin

Robert Jay Greenberg

Derrick Johnson

Louis A Campbell

Kevin Wilkin

Grace Myong Kim

Myron Howanec, Jr

Donald E Bobo, Jr

Harvey H Chen

Kelly Hobart McClure

Neil Hamilton Talbot

Jordan M Neysmith

Jerry Ok

Rongqing Dai

Scott M Loftin

Richard Agustin Castro

Mark Van Nest

Thomas H Chien

Paul A Schmidt

Visith Chung

David S Lin

Peng Norasing

Isidro L Guerrero

Francis M Tran

James Singleton Little

Rajat N Agrawal

Salvador Marquez

Sanjay Gaikwad

Cindy Woo

Qinggang Zeng

Hilda Zhang Fann

Mark Humayan

Jessica Guttenberg

Arup Roy

Yaron Keidar

Sumit Yadav

Steven M Ford

Lynn T Dang

Alexander H Siemons

Javier A Sanguinetti

Susan McCord

Gerald B Gollinger

William A Maywald

Virginia Qi Lin

Hao-Chung Yang

Xiaofan Wu

Myron Howanec

Mark Salman Humayun

Matthew T Winston

James A Davidson

Van Le Huynh

Andrew Phung

Rodolfo Rodriguez

Amy E Munnelly

Ankita Bordoloi Gurunath

Avina Gupta

Kurt Kelly Reed

Thomas Y Chien

James R Yamada

Amanda Grace Sall

Sooji Van Echten

Kevin Wilkins

Alain F Carpentier

William Charles Brunnett

Brian V Mech

John F Migliazza

Anand R Rao

Richard A Castro

Ankita Bordoloi

Quinggang Zeng

Alain Carpentier

Donald E Bobo

Kelly H Mcclure

Thomas Chien

Jr Bobo Donald E

Nest Mark Van

Paul A Schimidt

Chien Thomas

Sensor-integrated prosthetic valves that can comprise a variety of features, including a plurality of valve leaflets, a frame assembly configured to support the plurality of valve leaflets and define a plurality of commissure supports terminating at an outflow end of the prosthetic valve, a sensor device associated with the frame assembly and configured to generate a sensor signal, for example, a sensor signal indicating deflection of one or more of the plurality of commissure supports, and a transmitter assembly configured to receive the sensor signal from the sensor device and wirelessly transmit a transmission signal that is based at least in part on the sensor signal.

Valve implant with integrated sensor and transmitter

A prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be reshaped into an expanded form in order to receive and/or support an expandable prosthetic heart valve therein is disclosed, together with methods of using same. Interlocking members or flexible loops are included to limit expansion of the valve to one or two valve sizes, for example, with a 2-mm gap between each valve size. The valve may include an internal structural band with overlapped free ends having structure for limiting expansion, or external loops of suture may be added to the fabric covering which limits expansion.

Limited expansion heart valves

A prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be reshaped into an expanded form in order to receive and/or support an expandable prosthetic heart valve therein is disclosed, together with methods of using same. The prosthetic heart valve may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander.

Heart valve stents adapted for post-implant expansion

A minimally-invasive annuloplasty ring for implant at a mitral annulus. The annuloplasty ring has an inner core member with a C-shaped plan view that generally defines an oval with a major axis and a minor axis, and is symmetric about the minor axis. A posterior portion of the core member bisected by the minor axis has a thicker radial dimension than a pair of free end regions terminating on an anterior side of the core member. The radial thickness smoothly transitions between the posterior portion and the end regions. The inner core member may be covered with a fabric, and is a superelastic metal so that it can be straightened out and delivered through an access tube. The curvatures and thicknesses around the core member are selected so that the strain experienced when straightened does not exceed 7-8%.

Minimally-invasive low strain annuloplasty ring

A holder for a hybrid heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The hybrid heart valve includes a non-expandable, non-compressible prosthetic valve and a self-expandable anchoring stent, thereby enabling attachment to the annulus without sutures. A first suture connects the holder to the valve and constricts an inflow end of the anchoring stent. A second suture connects the holder to the valve and extends down three holder legs to loop through fabric on the valve. Both sutures may loop over a single cutting well on the holder so that severing the first and second sutures at the single cutting well simultaneously releases the tension in the first suture, permitting the inflow end of the anchoring stent to expand, and disconnects the valve holder from the prosthetic heart valve.

Holder and deployment system for prosthetic heart valves

A heart valve sizer and sizer cover are provided for determining the size of a heart valve annulus. The valve sizer can include a handle, a shaft extending distally from the handle, a sizing element coupled to the distal end of the shaft, the sizing element being movable between a first retracted position and a second expanded position, and a sizer cover. The sizer cover can be formed from a continuous sheet of material configured to surround at least a portion of the sizing element of the heart valve sizer so as to guard against entanglement of the sizing element with structures of a human heart.

Protected adjustable heart valve sizer

A prosthetic heart valve has a plurality of valve leaflets that control directional flow of blood through a heart and a stent structure having a plurality of commissure posts supporting the valve leaflets. The stent structure has a covering over the plurality of commissure posts and has a sewing ring at an inflow end of the stent structure. Each of the plurality of commissure posts has a tip and a suture loop is attached to the covering at a location adjacent to or on the tip of the commissure post. Each suture loop provides a passage for a suture to pass through between the covering and the suture loop.

Valve holder assembly with suture looping protection

Assembly of heart valves and intermediate adapter stent

Limited expansion valve-in-valve procedures

Compressible heart valve annulus sizing templates suitable for minimally-invasive or otherwise reduced accessibility surgeries. The sizing templates may be folded, rolled, or otherwise compressed into a reduced configuration for passage through an access tube or other such access channel. Once expelled from the access tube the sizing templates expand to their original shape for use in sizing the annulus. The templates may be formed of an elastomeric polymer material such as silicone, a highly elastic metal such as NITINOL, or both. Grasping tabs or connectors for handles permit manipulation from outside the body. A NITINOL wireform may be compressed for passage through an access tube and expelled from the distal end thereof into a cloth cover to assume a sizer shape.

Compressible heart valve annulus sizing templates

One-piece heart valve stents adapted for post-implant expansion

Holder and deployment system for surgical heart valves

Growing community of inventors

Irvine, CA, United States of America

Da-Yu Chang