Human Genome Sciences, Inc.

Other

Oklahoma Medical Research Foundation

System of Systems Analytics, Inc.

D Roxanne Duan

Steven M Ruben

Jian Ni

Reiner L Gentz

Paul A Moore

Patrick J Dillon

Timothy A Coleman

Donna Mendrick

Pablo Jimenez

Joachim R Gruber

Mark A Rampy

Craig A Rosen

Joan W Conaway

Ali Shilatifard

Reinhard Ebner

John M Greene

Jing-Shan Hu

Kimberly A Florence

Ralph Froman Alderson

Robert J Melder

Alan Rudolph

Ronald C Conaway

Renee Wegrzyn

Marianne Murphy

Jonathan R Moll

Ronald C Conway

Disclosed are novel peptides that are useful, for example, for detecting target proteins having a &#x3b2;-sheet secondary structure which may be associated with a disease, and for diagnosing and treating such a disease. Related methods and kits also are disclosed.

Conformationally dynamic peptides

The present invention relates to a novel follistatin-3 protein which is a member of the family of inhibin-related proteins. In particular, isolated nucleic acid molecules are provided encoding the human follistatin-3 protein. Follistatin-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of follistatin-3 activity. Also provided are diagnostic methods for detecting reproductive system-related disorders and disorders of the regulation of cell growth and differentiation and therapeutic methods for treating reproductive system-related disorders and disorders of the regulation of cell growth and differentiation.

Methods of treatment using antibodies to follistatin-3

This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as 'KGF-2' also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

Keratinocyte growth factor-2 polynucleotides

Method of treating reproductive system cancer by administering follistatin-3

Follistatin-3

Keratinocyte growth factor-2

This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as &ldquo;KGF-2&rdquo; also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

The present invention relates to a novel human protein called Fibroblast Growth Factor 15, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein.

Polynucleotides encoding fibroblast growth factor 15

The present invention relates to a novel human protein called Bone Marrow-Specific Protein (BMSP), and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, and/or preventing disorders related to this novel human protein.

Bone marrow-specific protein

The present invention relates to a novel IL-20 protein which is a member of the cytokine polypeptide family. In particular, isolated nucleic acid molecules are provided encoding the human IL-20 protein. IL-20 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL-20 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

Interleukin-20

ELL2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ELL2 polypeptides and polynucleotides in the design of protocols for the treatment of neoplastic disorders, among others and diagnostic assays for such conditions.

ELL2, a new member of an ELL family of RNA polymerase II elongation factors

Nucleic acid molecules encoding Follistatin-3

Growing community of inventors

Bethesda, MD, United States of America

D Roxanne Duan