Hoffmann-la Roche Inc.

Madrigal Pharmaceuticals, Inc.

Trius Therapeutics, Inc.

F. Hoffmann-la Roche Ag

D Keith Hester, Ii

Charles Howard Reynolds

Robert J Duguid

Ping Wang

Martha Jean Kelly

Lianhe Shu

Duk Soon Choi

Anna Chasnoff

Gang Dong

John M Finn

Rebecca Taub

Edwin L Crow

The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TR&#x3b2; mutation.

Methods of synthesizing thyroid hormone analogs and polymorphs thereof

Method of synthesizing thyroid hormone analogs and polymorphs thereof

Dosage forms or pharmaceutical compositions comprise a compound having the structure of Formula IV:  wherein n is a non-negative integer; wherein each Z is an oxazolidinone-containing moiety having antibiotic activity in vivo upon cleaving, wherein M is independently ORor NRR; wherein Rand Rare independently selected from the group consisting of H, an optionally-substituted hydrocarbyl residue or a pharmaceutically acceptable cation; wherein the compound in the dosage form or a pharmaceutical composition is present in an amount effective for treating or preventing an antibacterial infection in a mammalian subject. Methods of preparing and using these dosage forms or pharmaceutical compositions are also disclosed.

Oxazolidinone containing dimer compounds, compositions and methods to make and use

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Delmar, NY, United States of America

D Keith Hester, Ii