Multi-magnetics Inc.

Sarissa Inc.

D James Koropatnick

Frank S Prato

R Terry Thompson

Mateusz Rytelewski

Donna E Goldhawk

Mark D Vincent

Peter Ferguson

Rene Figueredo

Neil Gelman

The invention provides an improved modified magnetosome that contains more iron therein with the combination of the expressed genes. This is achieved by co-expression of (a) one or more bacterial magnetotactic genes to amplify iron uptake, compartmentalization and biomineralization in cells, with (b) one or more mammalian iron handling proteins that together augment(s) and/or regulate the cells iron pool. As a result, mammalian cells or bacterial cells that are transfected or transformed, respectively, can be more effectively tracked using various imaging technologies.

Co-expression of magnetotactic bacterial genes and genes encoding iron handling proteins in cells

Methods of treating cancer using antisense based therapies including antisense oligonucleotides of si RNAs directed against DNA double-strand break repair proteins such as BRCA2 or RAD51 are provided. The antisense based therapies can be used alone, in tandem or in combination with other cancer therapies, in particular with therapies that lead to DNA damage, inhibition of DNA repair or inhibition of DNA synthesis, such as radiation, platinum drugs, alkylating agents, PARP inhibitors, or inhibitors of thymidylate synthase.

Methods of treating cancer by inhibition of DNA repair proteins using antisense based therapies

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London, Canada

D James Koropatnick