St Jude Medical, Atrial Fibrillation Division, Inc

Medtronic, Inc.

St. Jude Medical, Cardiology Division, Inc.

Intermedics Inc.

Sulzer Intermedics, Inc.

Endorobotics Corporation

D Curtis Deno

Ram Kumar Balachandran

Stephan Paul Miller

Jeffrey A Schweitzer

Karen J Kleckner

Joseph Leo Sullivan

Robert W Stadler

Anthony David Hill

Lawrence J Mulligan

William John Havel

Vincent E Splett

Dale Eric Just

Ruth N Klepfer

David A Igel

John P Rosborough

Braden Eliason

Jeffrey M Gillberg

Eric Jon Voth

Valtino X Afonso

Dennis J Morgan

Tom Dean Bennett

David E Euler

Jiazheng Shi

Glenn C Zillmer

Hua Zhong

Stéphane Massé

Steven J Kim

Robert D Aiken

Troy Terrance Tegg

John E Burnes

Lev Abramovich Koyrakh

David A Anderson

Michael R S Hill

Kenneth M Anderson

Richard J O'Brien

Edwin G Duffin

Martin Maitre Grasse

Kathleen A Prieve

Ren Zhou

David R Bloem

Glen H Kastner

Richard J Shaw

John Anderson Hauck

Saurav Paul

David Prutchi

Fred William Chapman

Robert G Walker

Richard E Stehr

James V Kauphusman

Randolph K Armstrong

Tommy Dean Bennett

Jonathan P Roberts

Paul Gordon Krause

Orhan Soykan

John Charles Stroebel

Timothy G Curran

Patrick J Paul

Israel A Byrd

Lawrence J Stotts

Daniel Joe Potter

Maura G Donovan

Eric John Wilkowske

Jeffrey David Wilkinson

Robert T Taepke

Dwight H Warkentin

Paul M Stein

Nirav Vijay Sheth

Robert C Beck

Mark Kudas

Lubomir Velitchkov Dragnev

Lynn E Gilmour

Douglas J Cook

Brian C A Fernandes

Larry J Hull

Jennifer T Fujii

Michael B Cohn

Daniel I Sterling

Alec Vautravers

Nicholas F Pergola

Dat H Truong

David M Schneider

Daniel A Feeney

Braden J Eliason

Stéphane MassÉ

Israel Alexander Byrd

Martin M Grasse

Lynn Eleanor Clark

Rebn Zhou

An electrophysiological laboratory system comprises a subsystem configured to perform diagnostic and/or therapeutic functions, a medical device, and an interface module disposed therebetween. The medical device comprises a shaft having proximal and distal portions, high- and low-impedance electrical pathways disposed within the shaft, and an electrode disposed at the distal portion of the shaft and electrically coupled to one or both of the high- and low-impedance electrical pathways. The electrode is configured to perform diagnostic and/or therapy delivery functions. The interface module comprises a high-impedance channel configured to couple the high-impedance pathway of the medical device to the subsystem, and to attenuate magnetic resonance RF and gradient field pulses generated by the MRI system. The interface module further comprises a low-impedance channel configured to couple the low-impedance pathway of the medical device to the subsystem.

Electrophysiology laboratory system for use with magnetic resonance imaging systems

A system and method for assessing effective delivery of ablation therapy to a tissue in a body is provided. A three-dimensional anatomical map of the tissue is generated and displayed with the map defining a corresponding volume. An index is generated corresponding to a location within the volume with the index indicative of a state of ablation therapy at the location. The index may be derived from one or more factors such as the duration an ablation electrode is present at the location, the amount of energy provided, the degree of electrical coupling between an ablation electrode and the tissue at the location and temperature. A visual characteristic (e.g., color intensity) of a portion of the anatomical map corresponding to the location is then altered responsive to the index.

System and method for assessing effective delivery of ablation therapy

A system for determining electrophysiological data comprising an electronic control unit configured to acquire electrophysiology signals from a plurality of electrodes () of one or more catheters, select at least one clique of electrodes from the plurality of electrodes () to determine a plurality of local E field data points, determine the location and orientation of the plurality of electrodes, process the electrophysiology signals from the at least one clique from a full set of bipole subcliques to derive the local E field data points associated with the at least one clique of electrodes, derive at least one orientation independent signal from the at least one clique of electrodes () from the information content corresponding to weighted parts of electrogram signals, and display or output catheter orientation independent electrophysiologic information to a user or process.

System and method for local electrophysiological characterization of cardiac substrate using multi-electrode catheter

Electrode assemblies include segmented electrodes disposed on a catheter. The segmented electrodes can be constructed at the tip of the catheter or more proximally located. Tip electrodes can be constructed from an electrically-insulative substrate covered with a conductive material. The conductive material can be deposited on the electrically-insulative substrate to form a single tip electrode or multiple segmented electrodes. In some embodiments the tip electrode can include irrigation flow holes for irrigation. A method of manufacturing a tip electrode comprising a thin layer of conductive material deposited on an electrically-insulative substrate is disclosed. Segmented ring electrodes can be constructed from segmented ring electrodes that can be equally separated around a circumference of a catheter. The segmented ring electrodes can be formed into segmented electrode subassemblies that can then be joined to a catheter shaft.

Ablation catheter designs and methods with enhanced diagnostic capabilities

A system and method for obtaining an OIS coordinate frame comprising an electronic control unit configured to determine a local 3D electric field loop, create a zero mean version of E(t) over a depolarization interval, compute an &#x116; value at each of a plurality of time intervals, compute an initial estimate of &#x175; from a cross product of E and the &#x116; value for each of the plurality of time intervals, average the initial estimate of &#x175; from each of the plurality of time for a best estimate of &#x175;, determine a plurality of &#xe2;(&#x3b8;) values and using the corresponding {circumflex over (n)}(&#x3b8;) values, compute a composite match score, and choose at least one best value for &#xe2; and a best value for {circumflex over (n)}.

Systems and methods for orientation independent sensing

An electrophysiology catheter is provided. In one embodiment, the catheter includes an elongate, deformable shaft having a proximal end and a distal end and a basket electrode assembly coupled to the distal end of the shaft. The basket electrode assembly has a proximal end and a distal end and is configured to assume a compressed state and an expanded state. The electrode assembly further includes one or more tubular splines having a plurality of electrodes disposed thereon and a plurality of conductors. Each of the plurality of conductors extends through the tubular spline from a corresponding one of the plurality of electrodes to the proximal end of the basket electrode assembly. The tubular splines are configured to assume a non-planar (e.g., a twisted or helical) shape in the expanded state.

Basket for a multi-electrode array catheter

A catheter and patch electrode system is provided for use with an apparatus, such as an ablation generator, having a 4-wire interface for improved impedance measurement. The 4-wire interface includes a pair of source connectors across which an excitation signal is produced and a pair of sense connector wires across which the impedance is measured. The RF ablation generator may also produce an ablation signal across a source wire and an indifferent return patch electrode. The system further includes a cable that connects the generator to a catheter. The catheter includes a shaft having a proximal end and a distal end, with an ablation tip electrode disposed at the distal end. A source lead is electrically coupled to the tip electrode and extends through the shaft to the proximal end where it is terminated. An optional sense lead is also electrically coupled to the tip electrode and extends through the shaft to the proximal end. The system further includes a source return (e.g., skin patch) and a sense return (e.g., skin patch), either or none of which may be combined with the indifferent return, and if used may be placed on opposite sides of the patient for improved performance. The impedance sensor circuit produces an excitation signal across the source connectors, which is then carried to the catheter by the cable, then to the tip electrode, travels through the complex load (tissue volume), and returns to the generator via a patch electrode. The impedance is measured by observing the voltage drop across the sense connectors caused by the excitation signal.

System and method for measurement of an impedance using a catheter such as an ablation catheter

A method of refining an anatomical model includes acquiring a two-dimensional echocardiogram that has a variable intensity, relating the two-dimensional echocardiogram to a plurality of mapping points that exist in three-dimensional space, and determining a confidence value for each of two or more mapping points that corresponds to an intensity at a point on the two-dimensional echocardiogram.

Refinement of an anatomical model using ultrasound

A system and method are provided for determining electrophysiological data. The system comprises an electronic control unit that is configured to receive electrical signals from a set of electrodes, receive position and orientation data for the set of electrodes from a mapping system, compensate for position and orientation artifacts of the set of electrodes, compose cliques of a subset of neighboring electrodes in the set of electrodes, determine catheter orientation independent information of a target tissue, and output the orientation independent information to a display. The method comprising receiving electrogram data for a set of electrodes (), compensating for artifacts in sensor positions in the mapping system (), resolving the bipolar signals into a 3D vector electrogram in the mapping system coordinates (), manipulating observed unipolar voltage signals and the tangent component of the e-field to estimate the conduction velocity vector (), and outputting the catheter orientation independent information ().

Utilization of electrode spatial arrangements for characterizing cardiac conduction conditions

System and method for local electrophysiological characterization of cardiac substrate using multi-electrode catheters

An efficient system for diagnosing arrhythmias and directing catheter therapies may allow for measuring, classifying, analyzing, and mapping spatial electrophysiological (EP) patterns within a body. The efficient system may further guide arrhythmia therapy and update maps as treatment is delivered. The efficient system may use a medical device having a high density of sensors with a known spatial configuration for collecting EP data and positioning data. Further, the efficient system may also use an electronic control system (ECU) for computing and providing the user with a variety of metrics, derivative metrics, high definition (HD) maps, HD composite maps, and general visual aids for association with a geometrical anatomical model shown on a display device.

System and method for diagnosing arrhythmias and directing catheter therapies

A method and system for assessing proximity between an electrode and tissue is provided. The system includes an electronic control unit (ECU). The ECU is configured to acquire values for first and second components of a complex impedance between the electrode and the tissue, and to calculate an electrical coupling index (ECI) responsive to the first and second values. The ECU is further configured to process the ECI to determine the proximity of the electrode to the tissue. The ECU may be configured to calculate an electrical coupling index rate (ECIR) based on the calculated ECI and information relating to the change in location of the electrode, and to assess proximity based on the ECIR. Alternatively, the ECU may be configured to assess the proximity using the calculated ECI, as opposed to the ECIR.

System and method for assessing the proximity of an electrode to tissue in a body

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Andover, MN, United States of America

D Curtis Deno