Schering Corporation

Neogenesis, Inc.

Neogenesis Pharmaceuticals, Inc.

D Allen Annis

Seth N Birnbaum

Andrew N Tyler

Mark Birnbaum

Viyyoor Moopil Girijavallabhan

Alan B Cooper

Huw M Nash

Gerald Wayne Shipps, Jr

Jagdish A Desai

James J-s Wang

Hugh Y Zhu

Patrick J Curran

The present invention provides compounds of formula I wherein X, Y, R-Rare as defined herein. Compositions containing these compounds, and methods for inhibiting HCV RNA-dependent RNA polymerase and treating hepatitis C and related disorders using these compounds and compositions are also provided. 

Substituted 5-carboxyamide pyrazoles and [1,2,4]triazoles as antiviral agents

A technique for automatically analyzing mass spectrographic data from mixtures of chemical compounds has a series of screens designed to eliminate or reduce incorrect peak identifications due to background noise, system resolution, system contamination, multiply charged ions and isotope substitutions. With such a technique, mass spectrograph data analysis may be greatly simplified by the identification of probable spurious signals, and analysis will become simpler and more accurate.

Method for identifying compounds in a chemical mixture

A technique for automatically analyzing mass spectrographic data from mixtures of chemical compounds is described consisting a series of screens designed to eliminate or reduce incorrect peak identifications due to background noise, system resolution, system contamination, multiply charged ions and isotope substitutions. The technique performs a mass spectrum operation on a control sample, producing a first group of output values. Next, perform a mass spectrographic operation on a sample to be analyzed, producing a second group of output values. Select a first m/z ratio for a material expected to be present in the mixture from a predetermined library of calculated mass spectrometer output spectrums and subtract the value of the control sample at the expected output value from the value of the analyzed sample, and compare the difference to a predetermined value. If the value is greater than the predetermined value thus indicating that the signal is above the background noise level, generating a record at that m/z value for an expected material. Performing the same mass spectrum operation several times to eliminate random noise and background contamination. Next, identify peak values that don't have the expected peak width or proper retention time for the separation method. Identify multiply charged ions by examining peak separation. Examine the m/z location of the expected material and compare intensity at the expected m/z location with the intensity at the next lower m/z recorded peak to identify peaks related to atomic isotope substitution. With such a technique, mass spectrograph data analysis may be greatly simplified by the identification of probable spurious signals, and analysis will become simpler and more accurate.

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Cambridge, MA, United States of America

D Allen Annis