Lallemand Hungary Liquidity Management LLC

Ut-battelle, Inc.

Dartmouth College

Enchi Corporation

D Aaron Argyros

Nicky Caiazza

Trisha Barrett

Anne K Warner

Arthur J Shaw, Iv

Johannes Pieter Van Dijken

Adam Michael Guss

Daniel G Olson

Christopher D Herring

Jonathan Lo

The present invention provides for the manipulation of cofactor usage in a recombinant host cell to increase the formation of desirable products. In some embodiments, the invention provides for a recombinant microorganism comprising a mutation in one or more native enzymes such that their cofactor specificity is altered in such a way that overall cofactor usage in the cell is balanced for a specified pathway and there is an increase in a specific product formation within the cell. In some embodiments, endogenous enzymes are replaced by enzymes with an alternate cofactor specificity from a different species.

Engineering an increase in ethanol production by altering cofactor specificity

The present invention provides a microorganism capable of fermenting arabinose to a desired product such as ethanol. In some embodiments, the organism is also capable of fermenting xylose. In some embodiments, the organism is capable of fermenting arabinose and xylose, and expresses one or more cellulases.

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White River Junction, VT, United States of America

D Aaron Argyros