Universitè De Montpellier

Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Centre Hospitalier Universitaire De Montpellier

Université D'auvergne

Ecole Nationale Superieure De Chimie

Université´ D'aix-marseille

Université Montpellier 2 Sciences Et Techniques

Institut De Recherche Pour Le Developpement (ird)

Université Cote D'azur

Université Clermont Auvergne

Céline Crauste

Thierry Durand

Joseph Vercauteren

Philippe Brabet

Christian Hamel

David Cia

Laurent Guillou

Claire Vigor

Christian Perigaud

Suzanne Peyrottes

Francisco Veas

Nicolas Blondeau

Espérance Moine

The invention relates to compound of formula (I): in particular flavonoid derivatives (quercetin and catechin derivatives), for use in the prevention and/or the treatment of a disease or disorder involving both carbonyl and oxidative stresses.

Lipophenolic flavonoid derivatives useful to reduce carbonyl and oxidative stresses (COS)

The present invention relates to compound of formula (I): whereinR is O&#x2014;Ror Rand Rare identical or different and are each independently H, (C-C)alkyl, &#x2014;CO&#x2014;(C-C)alkyl or &#x2014;CO&#x2014;(C-C)alkenyl group, provided that at least one of Ror Ris H or (C-C)alkyl,Ris a &#x2014;CO&#x2014;(C-C)alkyl or &#x2014;CO&#x2014;(C-C)alkenyl group,or its pharmaceutically acceptable salts, racemates, diastereoisomers, enantiomers, or mixtures thereof,for use in prevention and/or treatment of a disease or disorder linked to an exacerbated vascular, lymphatic or mucosal permeability.

Uses of lipophenolic compounds

The present invention relates to a compound of formula (I) wherein: i is 0 or 1; j is 0 or 1; k is 0 or 1; Rand Rare in particular H, (C-C)alkyl, or a group of formula C(O)R; R is a, linear or branched, alkyl radical, comprising at least 19 carbon atoms; Ris H and k=0 when j=1; or, when j=0, Ris &#x2014;C(O)R or -L-C(O)R; L, U and L&#x2033; are linkers; wherein, when j=0, at least one of the groups R; Rand Rcomprises a radical R. 

Lipophenol compounds and uses thereof

The invention concerns a method for preparing monomer nucleotides or nucleotide analogues comprising the steps of: (1) coupling a soluble polyethylene glycol support provided with at least one diacid or ether-acid linker and a monomer nucleoside or nucleoside analogue to an amine group or hydroxyl group of the nucleoside with the aid of a coupling agent; (2) at least one step for phosphorylation of said nucleoside or nucleoside analogue coupled to said support with a phosphorylation agent; (3) cleavage of said support and recovery of at least one monomer nucleotide or nucleotide analogue. The nucleotides prepared are biological tools.

Method for preparing nucleotides and related analogues by synthesis on soluble substrate, and biological tools thus prepared

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Montpellier, France

Céline Crauste