Other

Novalyst Discovery

Cédric Catala

Alain Wagner

Charles Mioskowski

A method for selecting at least one catalyst from a catalyst library on the basis of the reactivity thereof in a chemical conversion process includes: (a) testing the catalytic activity of a first catalyst from said catalyst library with respect to a reaction medium containing, as the compounds to be converted, at least one reactivity probe having a labeling system and including at least one reaction unit capable of reacting in said chemical conversion; (b) analyzing the reaction medium after said catalytic test for the purpose of qualitatively and/or qualitatively characterizing the resulting compounds; (c) repeating steps (a) and (b) for at least one other catalyst in said library; and (d) comparing the analysis results for each catalyst in order to characterize at least one catalyst having the required reactivity in said chemical conversion.

Method of use for characterizing the catalytic reactivity of catalyst(s)

The invention relates to a method for the synthesis of two isomers, at function OH, alone or in mixtures, of amino acids &#x3b1; or the derivatives thereof, having general formula (B), wherein: linkage C&#x2014;O of the 4-position carbon (represented by symbol) denotes one or other of isomers III or IV, or mixtures thereof. Moreover, Rand Rrepresent: a hydrogen atom; or either Ror Rrepresents a hydrogen atom and the other substituent is a radical R, an acyl group &#x2014;COR, such as acetyl, or a functional group &#x2014;COOR, &#x2014;SOR, &#x2014;N (R, R), Rand R, which are identical or different, representing a C1-C12 linear or branched alkyl radical, optionally substituted, an aryl group with one or more aromatic rings and heterocycles, comprising between 5 and 8C, optionally substituted, or aralkyl, the alkyl substituent and the aryl group being as defined above; or Rand Rboth represent a substituent as defined above. Rrepresents a hydrogen atom or Rand Rhas the significance of R. The invention is characterised in that it comprises: the isomerisation of a compound having formula (I), wherein R, R, R, Rand Rare as defined above, such as to produce a compound having formula (II); and the reduction of the carbonyl function thereof which, depending on the catalytic system employed and the formula (I) compound used, produces one of the isomers having general formula (III) or (IV) or a mixture thereof having formula (B). The invention can be used for the synthesis of (2S, 3R, 4S)-4-hydroxyisoleucine.

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Mundolsheim, France

Cédric Catala