Aventis Pharma S.a.

Sanofi-a Ventis Deutschland Gmbh

Sanofi

Cécile Combeau

Hans Matter

David William Will

Patrick Mailliet

Karl Schoenafinger

Jean-Christophe Carry

Anke Steinmetz

Michel Tabart

Laurent Schio

Michel Cheve

Ingrid Sassoon

Conception Nemecek

Fabienne Thompson

Karl Schönafinger

Thomas Rooney

Franck Halley

Swen Hoelder

Bernard Baudoin

Sylvie Wentzler

Gilles Tiraboschi

François Clerc

Christine Delaisi

Günter Müller

Eric Bacqué

Thorsten Naumann

Marielle Chiron

Sylvie Gontier

Swen Hölder

Alain Krick

Günther Müller

Dominique Le Suisse

Sylvette Lachaud

Disclosed are compounds of the general formula (I), where the definition of the substituents A, B, D, E, Rand Rare detailed in the description, and the physiologically tolerated salts thereof, a process for the preparation of these compounds and their use as pharmaceuticals.  These compounds are kinase inhibitors, in particular inhibitors of the kinase CDK2 (cyclin-dependent kinase 2).

4-benzimidazol-2-ylpyridazin-3-one derivatives

The present invention relates to novel pyridazinone derivatives of the general formula (I) wherein 

Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them

The present invention relates to novel compounds derived from indazoles or indoles of formula (1) or formula (2), to methods for treating tumors or cancerous cells with compounds of formula (1) or formula (2) and to pharmacaetutical compositions comprising a pharmaceutically acceptable carrier and a compound of formula (1) or formula (2) 

Indazole or indole derivatives, and use thereof in human medicine and more particularly in oncology

The invention relates to compounds of formula (I)in which Ris chosen from the group consisting of:in which Ris a C-Calkyl groupin which X may be Cl, Br, or Fin which n is between 1 and 3, in the E or Z form, or a mixture of the two isomeric forms, possessing antimitotic, antiproliferative and antivascular properties through inhibition of the polymerization of tubulin into microtubules

Compounds derived from oxindoles and their therapeutic application in cancer treatment

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Fontenay aux Roses, France

Cécile Combeau