Imperial Chemical Industries Limited

Zeneca Limited

Imperial Chemical House

Ici Americas, Inc.

Cyrus J Ohnmacht

Diane A Trainor

Keith Russell

Keith H Gibson

Robert T Jacobs

Ashokkumar Bhikkappa Shenvi

Scott Carson Miller

Chris Allan Veale

Robert Toms Jacobs

Robert J Harris

James Roy Empfield

Ying K Yee

Mark M Stein

Joseph J Lewis

Janet Marie Forst

Paul James Warwick, Jr

Michael Thaddeus Klimas

Marc Ornal Terpko

Jeffrey B Malick

Russell Keith

Compounds of formula I ##STR1## wherein Q.sup.1, Q.sup.2, Q.sup.3, and Q.sup.4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.

Cyclic amide derivatives for treating asthma

Compounds of formula I: ##STR1## wherein, ring C, A--B, R.sup.1, n, R.sup.2, and R.sup.3 have any of the meanings given in the specification, and their pharmaceutically acceptable salts are useful in the treatment of urinery incontinence. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.

Therapeutic

Substituted piperidinobutyl nitrogen-containing heterocyclic compounds

Compounds of formula I, and pharmaceutically acceptable salts thereof, useful in the treatment of neuropsychiatric disorders such as psychoses; pharmaceutical compositions comprising a compound of formula I and a pharmaceutically acceptable diluent or carrier; and methods of treating neuropsychiatric disorders comprising administering to a mammal (including man) in need of such treatment an effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof.

Therapeutic agents

Amides having formula I: ##STR1## wherein E, X, R.sup.2 and R.sup.3 have the meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable in vivo hydrolysable esters thereof, which are useful in the treatment of urinary incontinence. Further provided are processes for preparing the aides and pharmaceutical compositions containing them.

Method of preparing therapeutic amides

Compounds of formula I or I', ##STR1## wherein X and Y are independently selected from hydrogen, halo, and (1-6C)alkoxy;

Tricyclic antipsychotic compounds

Piperidine derivatives useful as neurokinin antagonists

Methods of treating asthma are provided which methods comprise administering to a mammal in need of such treatment an effective amount of a compound of Formula I ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sup.2, R.sup.3, R.sup.4, R.sup.10 and R.sup.11 have any of the meanings given in the specification.

Heterocyclic derivatives

Therapeutic amides

Amides having formula I: ##STR1## wherein E, X, R.sup.2 and R.sup.3 have the meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable in vivo hydrolysable esters thereof, which are useful in the treatment of urinary incontinence. Further provided are processes for preparing the amides and pharmaceutical compositions containing them.

Compounds of formula I ##STR1## wherein X and Y are H or halo; R.sup.2 is: [structures Ia, Ib or Ic;] ##STR2## R.sup.3 is selected from unsubstituted or substituted alkyl, aryl or heteroaryl groups;

Methanoanthrancenyl piperidyl antipsychotics

Methanoanthraceneyl methyl piperidinyl compounds

Growing community of inventors

Wilmington, DE, United States of America

Cyrus J Ohnmacht