Hoffmann-La Roche Inc.

F. Hoffmann-La Roche Ag

Cyrille Blintz

Mayumi Naito Bowen

Markus Hemminger

Flora Felsovalyi

Richard Dumont

Joshua Horvath

A prefilled syringe is disclosed that includes a barrel, a stopper displaceable within and defining a sealed chamber in an interior of the barrel, a liquid filled in the chamber of the barrel, and a plunger extending within the barrel. The stopper expels the liquid out of the barrel via an orifice when being forwarded towards the orifice by the plunger such that a volume of the chamber is reduced. The plunger includes a proximal portion, a distal portion and a rod portion extending between the proximal portion and the distal portion. The plunger is shaped to form a pathway between an opening of the barrel and a segment where the proximal portion of the plunger is neighboring the stopper such that a sterilizing agent can be provided through the opening of the barrel to the segment where the proximal portion of the plunger is neighboring the stopper.

Prefilled syringe and method of sterilizing a prefilled syringe

A syringe pack with a prefilled syringe () and a packaging () comprises: a barrel part () with an orifice () at a proximal end and a flange portion () at a distal end; a plunger part () extending through the distal end of the barrel part () into the barrel part (); a stopper () adjacent to a proximal end of the plunger part () and arranged inside the barrel part () such that a dosage chamber () is formed inside the barrel part (); and a drug substance arranged inside the dosage chamber (), wherein the prefilled syringe () is arranged in the packaging () and the packaging () is configured to allow external sterilization of the prefilled syringe () arranged in the packaging (). The packaging () comprises a containment part () having a fixing structure () which holds the barrel part () of the prefilled syringe () in a defined fix position; a constraining structure () which acts on the plunger part () of the prefilled syringe () to block a movement of the plunger part () of the prefilled syringe () in a distal direction; and a cover part () tightly closing the containment ().

Syringe pack and method of packing a prefilled syringe

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Basel, Switzerland

Cyrille Blintz