Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Université Cote D'azur

Université Nice Sophia Antipolis

Inserm

Cyril Ronco

Rachid Benhida

Stephane Rocchi

Robert Ballotti

Magali Plaisant

Antoine Millet

Nedra Tekaya

Emile Jaune

Oleksandr Grytsai

Stéphane Rocchi

The present disclosure relates to biguanide derivatives of formula (I) and their rearrangement products. The present disclosure also relates to the use of these compounds in a method for treating cancer, in particular melanoma. 

Biguanide derivatives and their rearrangement products for use in the treatment of cancer

The present invention relates to compound of general formula (I) Ris selected from H, aryl and alkyl, Ris selected from H, alkyl, aryl and CO&#x2014;R; Ris selected from H, halogen, alkyl, alkenyl, alkynyl, aryl, NHR, NRR, ORand SR; Ris selected from (C-C) alkyl, (C-C) alkenyl, (C-C) alkynyl and (C-C) aryl, Rrepresents H, R, aryl, OH, OR, O-aryl, SH, SR, S-aryl, CN, NO, CF, COOR, SONRR, CONRR, NH, NHR, NH-aryl, NRR, NHCORor aminoacyl; Ris alkyl optionally substituted with halogen, OH, SH, NH, O-alkyl, S-alkyl, NH-alkyl or NH-di(alkyl); Rand Ridentical or different are H or alkyl optionally substituted with halogen, OH, SH, NH, O-alkyl, S-alkyl, NH-alkyl or NH-di (alkyl), their pharmaceutically acceptable salts and/or isomers, tautomers, solvates or isotopic variations thereof. The compounds are useful for the treatment of cancers. 

Substituted hydrophobic benzene sulfonamide thiazole compounds for use in treating cancer

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Cyril Ronco