National Institute of Health and Medical Research

Eye Tech Care

Centre Leon Berard

University Claude Bernard - Lyon 1

Other

Tohoku University

Assistance Publique-Hopitaux De Paris

Université Pierre Et Marie Curie (Paris 6)

Carthera

Université Claude Bernard

Université Pierre Et Marie Curie

Vermon S.a.

Inserm

Carthera S.a.s.

Cyril Lafon

Jean-Yves Chapelon

Fabrizio Romano

Françoise Chavrier

Philippe Chapuis

Alain Birer

Laurent Farcy

Jean-Louis Mestas

Alexandre Carpentier

Michael Canney

Stefan Catheline

Francoise Chavrier

An Nguyen-Dinh

Dominique Cathignol

Rémi Dufait

Rémi Souchon

René Milleret

Thomas Charrel

William Apoutou N'Djin

Christophe Notard

Shin-Ichiro Umemura

Bernard Greillier

Maxime Lafond

Kévin Beccaria

Frederic Prat

Pol Grasland-Mongrain

Michael Sean Canney

Elodie Constanciel

Kevin Beccaria

William Apoutou N'djin

This method for determining a mechanical property of a layered soft material, includes steps of a) generating an ultrasound wave (W) focused towards a first point (P) of the material, said wave, upon interacting with a layer of said material, generating in turn a Lamb (L) wave propagating into said layer of the material, b) measuring, at a second point (P) of the material belonging to said layer, a physical parameter of the generated Lamb wave, c) automatically determining the mechanical property of the layered soft material, based on the measured physical parameter. Step a) is performed by exciting a first ultrasonic transducer () with a first excitation signal (S) during at most 50 ms, step b) is performed by exciting a second ultrasonic transducer () with a second excitation signal (S) during at most 0.5 ms, to generate multiple excitation ultrasound waves (W) focused towards said second point (P) and, then, collecting multiple reflected waves (W') emitted in response, said first and second ultrasonic transducers each comprises an oscillator having a quality factor equal to or superior to 100, preferably equal or superior to 1000.

Method for determining a mechanical property of a layered soft material

Method and system for localizing a region of interest in a medium in which cavitation occurs. Method for localizing a region of interest (R) in a medium (M) in which cavitation occurs, the method comprising the steps consisting in: producing cavitation in the region of interest (R), the cavitation generating an acoustic signal, at each of at least three separate positions, detecting a cavitation signal representative of the acoustic signal of the cavitation, for at least two pairs of cavitation signals, determining a delay between the cavitation signals of each pair of cavitation signals, calculating a localization of the region of interest (R) based on the delays and the positions.

Method and system for localizing a region of interest in a medium in which cavitation occurs

This device () for generating ultrasonic waves in a target region of a soft solid, includes at least two ultrasound sources (), light sources () distributed around a central axis (X) of the device (), for enlightening a zone of the soft solid via subsurface scattering, and a video camera (), for capturing images of the zone enlightened by the lighting means. The ultrasound source (), the light sources () and the video camera () are mounted on a body of the device () and oriented toward a common target zone which includes a focal point of the ultrasound sources (). A boresight of the video camera is aligned on the central axis (X).

Device and system for generating ultrasonic waves in a target region of a soft solid and method for locally treating a tissue

An interstitial ultrasound thermal ablation applicator for conformal treatment of an inhomogeneous tumor lesion includes: a body having a longitudinal axis; and a plurality of array transducers mounted on the body, arranged side by side and having azimuth directions parallel to the longitudinal axis of the body, and having outer faces disposed in a polygonal arrangement; the plurality of array transducers having predetermined elevation dimensions defined for directing emitted ultrasonic energy to obtain a conformal volume treatment of the tumor lesions. An electronic driving method for driving an applicator having multiple independent transducer elements arranged in rows and columns includes: controlling focal parameters of each row and column of transducer elements; and controlling a contribution of each row and column of transducer elements in a manner to provide a conformal ablated volume.

Interstitial ultrasonic disposable applicator and method for tissue thermal conformal volume ablation and monitoring the same

This shear wave imaging method, for collecting information on a target region (R) of a soft solid (S), comprises at least the steps a) of generating at least one shear wave (SW) in the target region, and b) of detecting a propagation pattern of the shear wave in the target region. Step a) is realized by applying to particles of the target region (R) some Lorentz forces resulting from an electric field (E) and from a magnetic field (B). At least one of the electric field (E) and the magnetic field (B) is variable in time, with a central frequency (f) between 1 Hz and 10 kHz. Alternatively, both the electric and magnetic fields (E, B) are variable in time, with a central difference frequency (&#x394;f) between 1 Hz and 10 kHz. The shear wave imaging installation comprises a first system () for generating at least one shear wave (SW) in the target region (R) and a second system () for detecting a propagation pattern of the shear wave. The first system includes first means () to apply an electric field (E) through the target region (R) and second means () to apply a magnetic field (B) through the target region. The first and second means are configured to apply to particles of the target region some Lorentz forces resulting from the electric field (E) and the magnetic field (B), where at least one of these fields is a quantity variable in time, with a central frequency (f) between 1 Hz and 10 kHz, or both fields are quantities variable in time, with a central difference frequency (&#x394;f) between 1 Hz and 10 kHz.

Shear wave imaging method and installation for collecting information on a soft solid

The method determines parameters to generate confocal ultrasound beams (B,B) inside a medium (), and uses a device () comprising first and second ultrasound means () and first and second displacement members () for moving the ultrasound means (). The parameters include signals s,sto the ultrasound means (), and the positions x,xof the ultrasound means (). The parameters are optimized for having a minimum amplitude a,aof the signals s,sand having an acoustic effect inside the medium ().

Method for determining optimized parameters of a device generating a plurality of ultrasound beams focused in a region of interest

A device for treatment of an ocular pathology characterized in that it comprises at least one eye ring () wherein the proximal end of said eye ring () is suitable to be applied onto the glove and means () to generate ultrasound beam fixed on the distal end of the eye ring (), said means to generate ultrasound beam presenting a concave segment shape conformed along a single curvature corresponding to a single direction wherein the concavity is designed to be tuned towards the eyeglobe.

High intensity focused ultrasound device with a concave segment shaped transducers for treatment of ocular pathology

A device for treatment of an ocular pathology characterized in that it comprises at least one eye ring () wherein the proximal end of said eye ring () is suitable to be applied onto the globe and a generator () to generate ultrasound beam fixed on the distal end of the eye ring (), the generator to generate ultrasound beam presenting a concave segment shape conformed along a single curvature corresponding to a single direction wherein the concavity is designed to be tuned towards the eyeglobe.

High intensity focused ultrasound device with a concave segment shaped transducer for eye treatment

A method of treating an ocular pathology by generating high intensity focused ultrasound onto at least one eye's area, the method comprises at least the following steps of: positioning onto the eye a device capable of directing high intensity focused ultrasound onto at least one annular segment, and generating high intensity focused ultrasound energy onto the segment to treat at least one annular segment in the eye. Another embodiment of the invention concerns a device for treatment of an ocular pathology comprising at least one eye ring wherein the proximal end of the eye ring is suitable to be applied onto the globe and a high intensity focused ultrasound beam generator to generate ultrasound beam fixed on the distal end of the eye ring capable of treating the whole circumference of the eye in one step.

High intensity focused ultrasound device and method for ocular pathology treatment

The present invention relates to an apparatus for the treatment of a brain affection, which comprises at least one implantable generator () made of non-ferromagnetic material comprising a casing (), an ultrasound generating treating device () positioned into said casing to induce brain affection treatment by emission of ultrasound waves, and means for fastening the implantable casing into the skull. The apparatus further comprises a power controller (PwC) to supply electricity to the treating device of the implantable generator and to set and control its working parameters, and connecting means () to connect the power controller and the treating device of the implantable generator. A method for treating a brain affection with such an apparatus is also disclosed.

Apparatus for the treatment of brain affections and method implementing thereof

The present invention relates to a device for treating an ocular pathology, including a ring () comprising a proximal end intended to be in contact with an eye of a patient, and a distal end intended to receive ultrasound generating means (), wherein the device additionally includes at least one reflector () for reflecting and focusing ultrasound generated by the generation means.

Device for ocular ultrasound therapy having a reflector

The present invention relates to a device for treatment of an ocular pathology, the device comprising at least one eye ring wherein the proximal end of said eye ring is suitable to be applied onto the globe and means to generate ultrasound beam fixed on the distal end of the eye ring, said means to generate ultrasound beam presenting a concave segment shape conformed along a single curvature corresponding to a single direction wherein the concavity is designed to be tuned towards the eyeglobe.

Parameters for an ultrasound device comprising means to generate high intensity ultrasound beam

An ultrasound applicator for heating, via an internal path, an ultrasound absorbent medium, includes an application head having a longitudinal axis and including at least one ultrasonic transducer having a planar emission face and an opposite face, a leakproof membrane which overlays and is spaced from the emission face, and which is transparent to ultrasound, and means for preventing propagation of ultrasound from the opposite face; means for remotely connecting the transducer to an electricity generator; and means for providing ultrasound coupling with the membrane. The planar emission face emits ultrasound waves through the membrane and in a direction that is substantially perpendicular to the emission face, such that the waves emitted are substantially planar and do not diverge in the vicinity of the transducer and the application head.

Ultrasound applicator for heating an ultrasound absorbent medium

Growing community of inventors

Lyons, France

Cyril Lafon