Janssen Pharmaceutica Nv

Aragon Pharmaceuticals, Inc.

Bristol-myers Squibb Compnay

Cyril Ben Haim

Yi Xiao

Andras Horvath

Ioannis Nicolaos Houpis

Bin Zheng

Johan Erwin Edmond Weerts

Matteo Conza

Diego Fernando Domenico Broggini

Nicolas Cuniere

Yu Fan

Sergei Kolotuchin

Eric M Simmons

Carolyn S Wei

Simon Albert Wagschal

Changxia Yuan

Jennifer Albaneze-Walker

Philip James Pye

Sebastien François Emmanuel Lemaire

Subha Mukherjee

Kostiantyn Chernichenko

Duy Chi Trung Cao

Thomas Joost Martti Michiels

Florian Damien Medina

Dominique Paul M Depré

Johan Erwin Edmond

Amarjit Singh

Philip Pye

Johan Erwin Weerts

Disclosed is a process for the preparation of certain intermediates, e.g. the following compound: which intermediate and processes are useful in the preparation of a BTK inhibitor, such as ibrutinib.

Processes and intermediates for preparing a Btk inhibitor

Disclosed are processes and intermediates for the preparation of compound (X), which is currently being investigated for the treatment of prostate cancer. 

Process for the preparation of a diarylthiohydantoin compound

Processes for the preparation of a diarylthiohydantoin compound

Disclosed is a process for the preparation of the following compounds: where R, Rand Rhave the definitions in the description, as well as a process to prepare other intermediates that may be useful to synthesize downstream products, especially compounds that are useful as medicaments, for instance Bruton's tyrosine kinase (Btk) inhibitors such as ibrutinib. Also disclosed are other processes, other intermediates and compounds per se.

Processes and intermediates for preparing a medicament

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Beerse, Belgium

Cyril Ben Haim