Medtronic, Inc.

Medtronic Vascular, Inc.

Other

University of Minnesota

Cynthia T Clague

Paul T Rothstein

James R Keogh

Jason L Quill

Raymond W Usher

Ana Menk

Scott Eric Jahns

Alexander J Hill

Jeffrey D Sandstrom

Christopher P Olig

Philip Jon Haarstad

Joel R Racchini

Michael M Green

Timothy G Laske

Carol Elsa Eberhardt

Joseph C Morrow

Jerald Lamont Redmond

Kshitija P Garde

Janice Lynn Shay

Sarah E Ahlberg

Mark J Capps

Billie J Millwee

Debra A Taitague

Richard T Stone

Matthew David Bonner

Paul A Pignato

Karen Pilney Montpetit

Frank D Dorman

Geoffrey Orth

Karan Punga

Gary W Guenst

Douglas Dean Nippoldt

Stephen Roller

Robert Cushing Hamlen

Eric Meyer

Timothy A Miller

Michael Bateman

Michael P Sullivan

Timothy Petersen

Joseph E Poissant

Donald W Hegeman, Iii

Mark T Stewart

Igor Kovalsky

John R Liddicoat

Paul Anthony Iaizzo

Steven C Christian

Roderick E Briscoe

Daniel Grant Ericson

Michael Krivoruchko

Tom P Daigle

Thomas Daigle

Wei Wang

Glenn C Stante

Tracey Tien

Michael J Hobday

Scott C Mosher

Asha Shrinivas Nayak

Cathleen A Bergin

Daniel Cheek

Chris M Coppin

Elizabeth A Schotzko

Mark W Torrianni

Robert Reetz

Katherine S Jolly

Rany Huynh

Devin Gosal

Susan Peterson

Perry L Blackshear, Jr

Misha Young

Dean Christiansen

Alfonso D'Alessandro

Martin J Clements

Scott Janis

Brian T McHenry

Ana R Buhr

Michael Green

Mostafa Toloui

Sara Simma

Martin Clements

Brian Mchenry

Georg Bortlein

Jams R Keogh

A transcatheter prosthesis includes a stent, a prosthetic valve component, and an anti-paravalvular leakage component. The anti-paravalvular leakage component is coupled to the stent and includes an inner skirt, an outer wrap, a cavity, an opening, and a one-way valve. The inner skirt is disposed on an inner surface of the stent and has an inflow end and a downstream end. The outer wrap is disposed around an outer surface of the stent and has an inflow end coupled to the inflow end of the inner skirt and a downstream end. The cavity is formed between an outer surface of the inner skirt and an inner surface of the outer wrap. An opening is disposed between the inner skirt and the outer wrap. The one-way valve includes a flap at the opening configured to open to allow blood flow into the cavity but prevent blood flow out of the cavity.

Prosthesis with anti-paravalvular leakage component including a one-way valve

Stented prosthetic heart valves comprising a stent frame having a compressed arrangement for delivery within a patient's vasculature and an expanded arrangement for deployment within a native heart valve. The stented prosthetic heart valves including a paravalvular leakage prevention or mitigation wrap that encircles a stent frame and is formed of a flexible material having a variable diameter defined by a greatest distance between the wrap and the stent frame. The wrap further includes a first end coupled to the stent frame and an opposing second end that is not coupled to the stent frame, wherein the wrap can selectively enlarge its diameter in situ via movement of the second end. Devices for and methods of selectively deploying the wrap are also disclosed.

Stented prosthetic heart valve having a wrap and delivery devices

Systems and methods for modifying a heart valve annulus in a minimally invasive surgical procedure. A helical anchor is provided, having a memory set to a coiled shape or state. The helical anchor is further configured to self-revert from a substantially straight state to the coiled state. The helical anchor is loaded within a needle that constrains the helical anchor to the substantially straight state. The needle is delivered to the valve annulus and inserted into tissue of the annulus. The helical anchor is then deployed from the needle (e.g., the needle is retracted from over the helical anchor). Once deployed, the helical anchor self-transitions toward the coiled shape, cinching engaged tissue of the valve annulus.

Mitral valve annuloplasty systems and methods

Described is a prosthetic valve, comprising: an expandable stent including an inner lumen and having a first and a second end; and a spring attached to the first end of the expandable stent; wherein the expandable stent and the spring can expand radially to a desired diametric configuration in order to anchor the prosthetic valve at an implantation position in a body lumen. Related systems and methods.

Transcatheter valve with torsion spring fixation and related systems and methods

Helical coil mitral valve annuloplasty systems and methods

A stented valve having at least one leaflet made of pericardium or other material having a relatively thin profile at the annulus. The leaflets are attached via chords to a stent frame, where the chords are positioned to mimic the native valve anatomy and functionality. In particular, the valves of one exemplary embodiment of the invention are sized to replace a mitral valve and therefore the chords are arranged to prevent prolapse of the leaflets into the atrium. The stented valve has a relatively short height at its annulus due to the positioning of the chords. In addition, the stented valve is capable of being crimped to a small enough size that it can be delivered to the implantation site via transcatheter delivery systems and methods.

Prosthetic heart valve devices and methods of valve replacement

Aspects of the disclosure include sizing catheters and methods for determining the size and other physical parameters of an internal orifice or lumen. Embodiments include a sizing catheter assembly having a handle assembly and a catheter assembly including at least one catheter extending from the handle assembly. The catheter assembly also includes at least two sizers, which can be adjustably spaced from each other. Each of the sizers are configured to conform to respective portions of a lumen of a patient's anatomy. The sizing catheter is configured such that the sizers are configured to specify or determine first and second dimensions of the lumen and also distance between the sizers. The sizers can include valve leaflets or the sizing catheter can include a temporary valve. Additional aspects include software/methods of assessing and determining an appropriate implantable device that can include assessing the biomechanical interaction between the device and the anatomy.

Sizing catheters, methods of sizing complex anatomies and methods of selecting a prosthesis for implantation

A device for temporarily sealing an opening in a blood vessel is provided. The device comprises a cutting mechanism for creating an opening in a blood vessel and a seal for sealing the opening in the blood vessel. The seal is delivered through an inner lumen of a tool body coupled to the cutting mechanism. Methods for using the device to construct an anastomosis between two vessels are also provided.

Vessel sealing devices

Systems and methods of delivering and deploying a stented prosthetic heart valve having a wrap that is automatically deployed to prevent or mitigate paravalvular leakage. In various embodiments, during transcatheter delivery of the stented prosthetic heart valve, the wrap is extends beyond a stent frame of the stented prosthetic heart valve so that the profile of the stented prosthetic heart valve is not increased during delivery. The disclosed embodiments are arranged and configured so that upon expansion of a stent frame of the stented prosthetic heart valve, a plurality of elongated members automatically pull the wrap distally into a deployed arrangement.

Stented prosthetic heart valve having wrap and methods of delivery and deployment

Systems and methods for approximating tissue segments, such as mitral valve leaflets, on a minimally invasive basis. The system includes first and second approximation devices each including a magnetic component and an attachment mechanism. Each device is connected to a target tissue segment by the corresponding attachment mechanism. Upon deployment at a target site, the tissue approximation devices are magnetically attracted to one another, approximating the tissue segments and maintaining the tissue segments in the approximated state.

Devices, systems and methods for tissue approximation, including approximating mitral valve leaflets

Growing community of inventors

Minneapolis, MN, United States of America

Cynthia T Clague