The State University of New York

University of Utah Research Foundation

University System of Maryland

Cynthia J Burrows

Steven E Rokita

Heungsik Yoon

Thomas R Wagler

Henry S White

Ryuji Kawano

Na An

Xiaoying Chen

Aaron M Fleming

Hsing-Pang Hsieh

Methods, systems, and compounds for detecting modified nucleic acid bases are disclosed and described. The methods provide for detecting a nucleic acid lesion and can include directing a nucleic acid adduct into a channel, wherein the nucleic acid adduct includes a nucleic acid having a lesion and a current modulating compound coupled to the nucleic acid at the lesion (), and measuring a change in current through the channel in response to the current modulating compound to detect the lesion (). The method can optionally include forming the nucleic acid adduct. Also provided is a method for identifying the number of repeat nucleotides in at least a portion of a nucleic acid strand, a method of assigning a registration marker within a nucleic acid, and a method of obtaining sequence information from a nucleic acid comprising assigning a registration marker on the nucleic acid.

Detection of nucleic acid lesions and adducts using nanopores

The invention relates to a compound comprising a labeled nickel complex (FIG.) that is used to detect and purify nucleic acid sequences by forming an adduct between a specific nucleic acid base and the labeled nickel complex. The adduct can also be purified through a separation process, such as affinity chromatography 

Nickel-based reagents for detecting DNA and DNA-protein contacts

New steroidal polyamines have the structure of formula I or formula II: ##STR1## wherein R.sub.1 and R.sub.2 are independently N(R').sub.3.sup.+ or H in the .alpha.- or .beta.- position except both R.sub.1 and R.sub.2 are not H;

Steroidal polyamines

A process is provided for oxidatively modifying nucleic acids containing a target nucleotide. The nucleic acid is contacted with a polyaza metal complex in the presence of an oxidizing agent so that the nucleic acid is modified at or near the target nucleotide. Also provided are a kit for carrying out the process and a method for treating neoplastic growth by administering to a subject having neoplastic growth, an effective amount of a polyaza metal complex which is capable of modifying DNA.

Modification of DNA and oligonucleotides using metal complexes of

A method is provided for oxidizing alkenes to epoxides by treating the alkene with a transition metal ion complex which includes a salen or salophen derivative and peroxymonosulfate ion or hypochlorite ion in a two phase system with a phase transfer catalyst, a water phase having a pH from about 6 to about 12.9 and an inorganic solvent phase in which the complex is sufficiently soluble.

Oxidations using polyazamacrocycle metal complexes

A 13 or 14 member macrocyclic compound having the following ring nucleus: ##STR1## wherein: n=0 or 1;

Polyazamacrocycles and their metal complexes and oxidations using same

A 13 or 14 member macrocyclic compound having the following ring nucleus: ##STR1##

Growing community of inventors

Salt Lake City, UT, United States of America

Cynthia J Burrows