The United States of America, As Represented by the Secretary, Department of Health and Human Services

Cynthia Goldsmith

Larry J Anderson

Thomas G Ksiazek

Anthony Sanchez

Pierre E Rollin

Raymond Campagnoli

Cara Carthel Burns

William Allan Nix

M Steven Oberste

Paul A Rota

Suxiang Tong

James A Comer

Dean D Erdman

Mark A Pallansch

William J Bellini

Stephan S Monroe

Qi Chen

Shannon L Emery

Charles D Humphrey

Joseph P Icenogle

Teresa C T Peret

Sherif R Zaki

Stuart T Nichol

Michael D Bowen

Byron T Cook

Laura K McMullan

Jeanette Guarner

Aubree Kelly

William L Nicholson

Richard F Meyer

Christopher D Paddock

Wun-Ju Shieh

Described herein are the clinical and laboratory characteristics of two patients bitten by ticks and infected with a unique member of the genus(family Bunyaviridae) with a proposed name of Heartland virus (HRTLV). Provided herein are nucleotide and amino acid sequences of theisolates, primers and probes that specifically hybridize with theisolates, and antibodies specific for theproteins. Also provided are detection assays using thenucleic acid molecules, proteins, probes, primers and antibodies. Further provided are recombinantand their use for eliciting an immune response in a subject.

Pathogenic phlebovirus isolates and compositions and methods of use

Disclosed herein is a newly isolated human coronavirus (SARS-CoV), the causative agent of severe acute respiratory syndrome (SARS). Also provided are the nucleic acid sequence of the SARS-CoV genome and the amino acid sequences of the SARS-CoV open reading frames, as well as methods of using these molecules to detect a SARS-CoV and detect infections therewith. Immune stimulatory compositions are also provided, along with methods of their use.

Coronavirus isolated from humans

Growing community of inventors

Lilburn, GA, United States of America

Cynthia Goldsmith