Duke University

Other

Johns Hopkins University

Bioptigen, Inc.

Novason Corporation

Cynthia A Toth

Joseph A Izatt

Ronald F Overaker

Brian C Dodge

Stephanie J Chiu

Sina Farsiu

Xiao T Li

Peter Christopher Nicholas

Brooks W McCuen

Oscar M Carrasco-Zevallos

Robert Machemer

Christian B Viehland

Eric A Postel

Brooks W Mccuen

Eric L Buckland

William F Walker

Bradley A Bower

David Lee Guyton

Daniel X Hammer

Boris I Gramatikov

Kristina Irsch

Bennett R Groshong

Yuankai K Tao

Eric Postel

Richard E Davidsen

Gary D Noojin

Josheph A Izatt

Katrina Winter

Vincent Tai

Kai Seely

Moseph Jackson-Atogi

Marcin Stopa

William P Roach

Liangbo Shen

Ryan Imperio

Justin Migacz

Sharon Fekrat

Isaac Bleicher

Eric A Postal

Glenn J Jaffe

A retinal vessel shadow view optical coherence tomography (RVSV-OCT) image can be created by receiving, at an enhanced OCT processing system, volumetric OCT scan of a patient. The system can segment the volumetric OCT scan to determine layer boundaries and delineate a boundary of interest based on the determined layer boundaries of the segmented volumetric OCT scan. En face vascular information can be extracted to create an RVSV-OCT image by determining a first offset from the boundary of interest and a second offset from the boundary of interest; extracting volumetric data from an area between the first offset and the second offset to create a three-dimensional volume; and identifying a two-dimensional surface from the three-dimensional volume, the two-dimensional surface being the RVSV-OCT image. The RVSV-OCT image can be provided for analysis, for example, to evaluate retinal vascular disease in preterm infants at risk for retinopathy of prematurity.

En face retinal vessel shadow view optical coherence tomography images

Optical coherence tomography (OCT) imaging systems, handhold probes, and methods that use a field curvature to match a curved surface of tissue are disclosed. According to an aspect, an OCT imaging system includes optical elements to generate diverging light. The system also includes one or more mirrors and a lens system configured to scan the diverging light onto a curved surface of an object for imaging of the object.

Optical coherence tomography imaging systems, handheld probes, and methods that use a field curvature to match a curved surface of tissue

Systems and methods for providing surface contrast to display images for micro-surgical applications are disclosed. According to an aspect, an imaging system includes an OCT apparatus configured to capture OCT data of an eye. The OCT image data can include depth-resolved images of reflected light intensity over a period of time. The imaging system also includes a controller configured to determine movement of the eye relative to the OCT imaging field-of-view. The controller may also determine a location within the imaged portion of the eye which tracks with the eye movement. Further, the controller may apply a color gradient to render OCT images of the eye based on a position relative to the determined location of the eye tracking location. The controller may also control a display to display the OCT images with the applied color gradient.

Systems and methods for providing surface contrast to display images for micro-surgical applications

Systems and methods for long working distance optical coherence tomography (OCT). According to an aspect, an OCT system includes a reference arm. Further, the OCT system includes a sample arm operably connected to the reference arm. The sample arm includes a scanner configured to scan an optical beam. The sample arm also includes an objective positioned a predetermined distance from the scanner, configured to receive the optical beam, and to direct the optical beam to an object positioned at about the predetermined distance from the scanner for imaging of the object.

Systems and methods for long working distance optical coherence tomography (OCT)

Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges. For example, the image may be an ocular image showing layered structures or other features of the retina. The method may also include adding, to the graph, nodes adjacent to nodes along first and second sides of the graph. The added nodes may have edge weights less than the nodes along the first and second sides of the graph. Further, the method may include assigning start and end points to any of the added nodes along the first and second sides, respectively. The method may also include graph cutting between the start and end points for identifying a feature in the image.

Segmentation and identification of layered structures in images

Stereoscopic display systems and methods for displaying surgical data and information in a surgical microscope are disclosed herein. According to an aspect, a system includes first and second eyepieces. The system includes a display having first and second display portions, configured to display first images in the first display portion, and configured to display second images in the second display portion. The first image and the second image are projected along a first pathway and a second pathway. The system includes a first optical element positioned to relay the first images into the first eyepiece. The system includes a second optical element positioned to relay the second images into the second eyepiece.

Stereoscopic display systems and methods for displaying surgical data and information in a surgical microscope

The present invention is directed to a method and system for improved aiming during Optical Coherence Tomography (OCT) on young children and those unable to cooperate with OCT imaging by synchronization with retinal birefringence scanning (RBS). OCT is performed without knowing whether or not the subject is looking at the intended target. The present invention combines OCT retinal imaging, such as, but not limited to, time domain OCT, SDOCT, or SSOCT, with RBS technology that provides accurate information on the presence or absence of foveal fixation. Therefore, the present invention only analyzes data during foveal fixation. A system combining OCT with RBS is implemented such that both systems co-operate in a specified alignment, such that when the RBS fixation detection system detects alignment with the fovea of the eye, the OCT system will be aimed at the retinal region of interest, usually but not necessarily including the macular area.

Method and system for improving aiming during optical coherence tomography on young children by synchronization with retinal bifringence scanning

A surgical microscope assembly includes a microscope main objective and microscope imaging optics. The microscope main objective and microscope imaging optics define a viewing beam path that passes from a sample through the microscope main objective and the microscope imaging optics. The assembly includes an optical coherence tomography (OCT) unit having an illumination beam and a collection beam and a beamsplitter between the microscope main objective and the microscope imaging optics. The beamsplitter is configured to direct a portion of light from the microscope main objective to the microscope imaging optics and to direct another portion of light from the microscope main objective to the OCT unit collection beam. The beamsplitter is further configured to direct an illumination beam from the OCT unit to the microscope main objective and to the sample. A beam forming unit is between the OCT unit and the beamsplitter. The beam forming unit is configured to form the illumination beam of the OCT unit so as to generally correspond to a size of the microscope main objective.

Systems and methods for surgical microscope and optical coherence tomography (OCT) imaging

Methods, systems and computer program products are provided for acquiring an image set using optical coherence tomography (OCT). A first portion of a defined volume is scanned at a low-density sampling rate to obtain a plurality of low-density frames. A second portion of the defined volume is scanned at a high-density sampling rate, higher than the low-density sampling rate, to obtain at least one high-density frame. The low-density frames and the at least one high-density frame are combined to provide a complete mixed-density image set.

Methods, systems and computer program products for mixed-density optical coherence tomography (OCT) imaging

A method/system preserves annotations of different pathological conditions or changes that are recognized on cross-sections within a three dimensional volume of a patient's eye so that the annotations are maintained in a visible state in an en face projection produced with a SVP technique. it is thus possible to coregister the annotated conditions or changes with other types of two dimensional en face images such as images from other ophthalmic devices (e.g., angiography device, microperimetry device, autofluorescence device, fundal photography device.). The annotations are also maintained in a visible state in the coregistered image.

Method and system of coregistrating optical coherence tomography (OCT) with other clinical tests

Miniature surgical forceps are formed from a one-piece tubular member by opposed longitudinal channels machined in a distal end thereof so as to establish a radially opposed pair of unitary forceps jaws. Most preferably, the opposed channels are formed in the distal end of the rigid tubular member by means of electron discharge machining (EDM) techniques. The resulting opposed cross-sectionally arcuate jaw sections may be bent and/or further shaped to achieve the desired final jaw configuration. The inner surfaces of the forceps jaws thereby established may have a filler material deposited in such a manner so as to change the overall shape and/or geometric configuration of the jaws and thereby engineer them to a specific surgical purpose.

Method of making miniaturized surgical forceps

A hand-held surgical light assembly is provided with a light source, and a handpiece which is adapted to be grasped and manipulated by a user. The handpiece has a light guide with a proximal end optically connected to the light source, and a distal end which projects outwardly from said handpiece so as to direct light guided thereby onto a field of view determined by manipulation of the handpiece by the user. The handpiece includes a switch assembly which is operatively coupled to the light source to allow user selection between at least two different light intensities (e.g., essentially on/off) discharged by said light guide onto the field of view. In preferred forms, the switch assembly includes an electrically conductive inner base member and an electrically conductive outer tubular elastomeric member concentrically positioned in surrounding, but spaced relationship, with the inner base member. When contact between the inner base member and the outer elastomeric member is made, switch circuitry changes the visible light intensity of the visible light generated by the light source, e.g., by either directly modulating the current to the lamp itself, or by providing an electrically operable shutter assembly which masks the light generated by the light source. The former embodiment is especially well suited for surgical lights which are self-contained (i.e., have the light sources contained in the handpiece), while the latter is especially well suited for surgical lights which have remotely positioned light sources.

Intensity controllable hand-held surgical light

Growing community of inventors

Chapel Hill, NC, United States of America

Cynthia A Toth