Basf Aktiengesellschaft

Knoll Aktiengesellschaft

Knoll Atkiengesellschaft

Cynthia A Romerdahl

Gerhard Keilhauer

Xiao-Dong Qian

Marina Moran Moset

Joerg Rosenberg

Miguel Fernandez Brana

Peter Bousquet

Andreas Haupt

Bernd Janssen

Kurt Ritter

Jose Maria Berlanga

Hans-Heinrich Gruenhagen

Miguel F Bra Na

Andreas Kling

Dagmar Klinge

Teresa Barlozzari

Rainer Schlecker

Franz Emling

Jose Maria Castellano Berlanga

Juergen Heberger

Stefan Mueller

Jos E Berlanga

Ulrich Traugott

Jose Mc Berlanga

Maria Jp De Vega

Maria Jesus De Vega

Maria Jesus Perez De Vega

Mar Ia P Erez De Vega

This invention provides a method for treating cancer in an individual, wherein the cancer is a tumor in which endothelin is upregulated (e.g. tumors of the prostate, lung, liver, breast, brain, stomach, colon, endometrium, testicle, thyroid, pituatary, bladder, kidney, pancreas and meninges) by administering to the individual an effective amount of a compound of Formula I or Formula Ia, as describe herein.

Carboxylic acid derivatives, their preparation and use in treating cancer

Disclosed herein are compounds pharmaceutical compositions containing same of the formula

Bis-naphthalimides for the treatment of cancer

A process for producing solutions of active substances of low solubility, which comprises (1) dissolving the active substance with a phospholipid and a water-soluble lipid in an organic solvent, (2) evaporating the resulting solution to dryness, (3) taking up the residue in a strongly acidic buffer and stirring at elevated temperature until a colloidal solution is produced, (4) cooling the colloidal solution and adjusting to a pH of 6-7 and sterilizing. Particularly suitable for the process are lipids of the formula ##STR1## wherein m, a, b, x and y have the meanings indicated in the description.

Preparation of colloidal aqueous solutions of active substances of low

Antitumor peptides

Disclosed herein are compounds pharmaceutical compositions containing same of the formula 1. A compound of the Formula ##STR1## wherein X, X', X' and X'', A, B, D, R, and R' are as identified in the specification and their preparation. Pharmaceutical compositions containing same can be used in the treatment of cancer.

Novel bis-1,2-dihydro-3H-dibenzisoquinoline-1,3-diones and their salts, processes for their preparation, pharmaceutical compositions containing them and methods of using them to treat malignancies, mainly human solid tumor carcinomas.

Dihydrodibenzisoquinolinediones

This invention relates to 1-amino-3-phenoxy-propane-derivatives of formula 1: ##STR1## (in which A, B, R, R.sup.x, X and Z are defined as in the specification described) and methods for their preparation. These compounds may be used as modulators of multidrug resistance in cancer chemotherapy and for circumvention of resistance in the treatment of malaria.

1-amino-3-phenoxy propane derivatives as modulator agents and their

Asymmetrically substituted bisnaphthalimides

Novel peptides of the formula ##STR1## in which R.sup.1, R.sup.2, X, A, R.sup.3, B, D, E, R.sup.7, M, Q, a, b and d have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.

Peptides, the preparation and use thereof

Growing community of inventors

Wayland, MA, United States of America

Cynthia A Romerdahl