Tallac Therapeutics, Inc.

Curt W Bradshaw

Sukumar Sakamuri

Son Lam

Jaume Pons

Tracy Chia-Chien Kuo

Bang Janet Sim

Hong I Wan

Edward HyungSuk Ha

Bin Liu

Dingguo Liu

Laxman Eltepu

Bryan R Meade

Ayman Kabakibi

Giuseppe Dello Iacono

Joseph Stock

Edward Hyungsuk Ha

Immunomodulating polynucleotides are disclosed. The immunomodulating polynucleotides may contain 5-modified uridine, 5-modified cytidine, a total of from 6 to 16 nucleotides, and/or one or more abasic spacers and/or internucleoside phosphotriesters. Also disclosed are conjugates containing a targeting moiety and one or more immunomodulating polynucleotides. The immunomodulating polynucleotides and conjugates may further contain one or more auxiliary moieties. Also disclosed are compositions containing the immunomodulating polynucleotides or the conjugates containing one or more stereochemically enriched internucleoside phosphorothioates. Further disclosed are pharmaceutical compositions containing the immunomodulating polynucleotides or the conjugates and methods of their use.

Immunomodulating polynucleotides, antibody conjugates thereof, and methods of their use

The present disclosure provides for antibody-oligonucleotide conjugates, methods of preparation thereof, and methods of use thereof. Also provided are related compounds, compositions and kits.

Transglutaminase-mediated conjugation

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San Francisco, CA, United States of America

Curt W Bradshaw