Seoul National University

Snu Rdb Foundation

Chong Kun Dang Pharmaceutical Corporation

Hanwha Advanced Materials Corporation

Curie Ahn

Byeong Chun Lee

Jong Ik Hwang

Goo Jang

Bum Rae Cho

Ok Jae Koo

Dae Kee Kwon

Jung Taek Kang

Jae Seok Yang

Sang Hoon Lee

Su Jin Kim

In Chang Hwang

Eun Mi Lee

Sol Park

Bumrae Cho

Geon A Kim

Hye Jin Hong

Su Cheong Yeom

Byoung Gon Moon

Jaeseok Yang

The present invention relates to a transgenic pig in which an immune rejection response is suppressed during xenotransplantation, wherein a gene coding for heme oxygenase-1 (HO-1) and a gene coding for tumor necrosis factor receptor 1-Fc (TNFR1-Fc) are simultaneously expressed and a gene coding for &#x3b1;-1,3-galactosyltransferase (GGTA1) is knocked out; and a method for producing the same.

Transgenic pig which simultaneously expresses HO-1 gene and TNFR1-Fc gene, and comprises knocked-out GGTA1 gene, and use thereof

The present invention relates to a transgenic pig that expresses sTNFR1-Fc, wherein a gene encoding sTNFR1-Fc, which is a fusion protein of the extracellular domain of human soluble tumor necrosis factor receptor (sTNFR1) and an immunoglobulin Fc region, is introduced; a method for preparing the same; an organ isolated from the transgenic pig; a somatic donor cell line inserted with sTNFR1-Fc gene; a method for preparing a blood sample comprising sTNFR1-Fc; and a method for preparing human sTNFR1-Fc from the blood sample of the transgenic pig. As the transgenic pig can suppress immune response and inflammatory response by secreting an inhibitory substance that suppresses the activity of TNF-&#x3b1; in blood, it can be effectively used for xenograft. Furthermore, since the transgenic pig has a blood type O, it can be transplanted for suppressing inflammatory response, regardless of a blood type of recipient.

Transgenic pig expressing sTNFR1-Fc genes and the uses thereof

The present invention relates to a method for producing a transgenic pig in which immune rejection response is inhibited, and in which human HO-1 genes and TNFR1-Fe fusion genes are simultaneously expressed. The present invention also relates to a transgenic pig for organ transplantation, which is produced by the method, and in which immune rejection response is inhibited. The present invention also relates to a somatic-cell-donating cell strain for producing the transgenic pig, and to a method for producing organs, from the transgenic pig, in which the immune rejection response is inhibited.

Transgenic pig in which HO-1 and TNFR1-Fc are simultaneously expressed, and method for producing same

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Seoul, South Korea

Curie Ahn