Genentech, Inc.

Rqx Pharmaceuticals, Inc.

Opna Bio Sa

University of California

F. Hoffmann-la Roche Ag

Cuong Q Ly

Jacob Bradley Schwarz

Frederick Cohen

Michael F T Koehler

John A Flygare

Wayne Spevak

Jiazhong Zhang

Chao Zhang

Songyuan Shi

Wendy Lee

Yu Jiang

Vickie Hsiao-Wei Tsui

James John Crawford

Prasuna Paraselli

Po-Wai Yuen

Robert Higuchi

Matthew Volgraf

Paul Gibbons

Elisia Villemure

John Buell

Guosheng Wu

Marie-Gabrielle Braun

Philippe Bergeron

Joachim Rudolph

Peter Andrew Smith

Ramsay Beveridge

Zuojun Guo

Tucker Curran Roberts

Huiyong Hu

Benjamin Douglas Sellers

Leo Fu

Xianrui Zhao

Jack Walleshauser

Mark Vander Wal

Joseph P Lyssikatos

Avi J Ashkenazi

Fei Wang

Anthony A Estrada

Snahel Patel

Zhonghua Pei

Daniel Fred Ortwine

Georgette M Castanedo

Michael Siu

Emily J Hanan

Nicole Blaquiere

Kwong Wah Lai

Toby Jonathan Blench

Malcolm Huestis

Paul Colin Michael Winship

Jean-Philippe Leclerc

Jiang Yu

Yongsheng Chen

Alexandre Lemire

Liang Zhao

Zhiyong Yu

Tommy Lai

Kevin Hon Luen Lau

Benjamin Sellers

Robert I Higuchi

Calum McCleod

Nicole Alice Blaquiere

Compounds and methods for CD73 modulation and indications therefor

Described herein are phenoxy-pyridyl-pyrimidine compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula I structure or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such IRE1 modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Phenoxy-pyridyl-pyrimidine compounds and methods of use

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Macrocyclic broad spectrum antibiotics

Described herein are pyrimidinyl-pyridyloxy-naphthyl compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula I or I' structure: 

Pyrimidinyl-pyridyloxy-naphthyl compounds and methods of treating IRE1-related diseases and disorders

The present invention relates to certain thiazolopyrimidinone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

Thiazolopyrimidinones and methods of use thereof

The present invention provides for compounds of Formula I and various embodiments thereof, and compositions comprising compounds of Formula I and various embodiments thereof.  In compounds of Formula I, the groups R, R, R, R, R, R, m, n and the C-linked Ring have the meaning as described herein. The present invention also provides for methods of using compounds of Formula I and compositions comprising compounds of Formula I as DLK inhibitors and for treating neurodegeneration diseases and disorders.

Substituted dipyridylamines and uses thereof

The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, Q, X, X, Y, R, R, R, R, R', R, Rand R&#x2032; are as described herein.

Pyrrolidine inhibitors of IAP

Disclosed are compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR). 

Pyrimidine compounds, compositions and methods of use

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Cuong Q Ly