Allgenesis Biotherapeutics Inc.

Nanjing Noratech Pharmaceuticals Co., Ltd

Noratech Pharmaceuticals, Inc.

Cuixia Zhang

Fei Liu

Wei Dong Wang

Pan Chen

Lulu Wang

Chenggang Lin

Chunyan Zhou

Tan Nguyen

Weiming Jiang

Chin-Yu Lai

Haolong Zhang

Crystalline forms of free base 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-phenylamino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone and preparation methods thereof are provided; the pharmaceutical formulations containing the crystalline forms and their use in the treatment of diseases, particularly angiogenic eye diseases are also provided.

Crystalline forms of 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-phenylamino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone

The present invention relates to a donepezil derivative of general formula (I) or a pharmaceutically acceptable salt thereof, wherein R in the formula is as disclosed herein; and a method for preparation thereof; and a composition comprising an effective amount of a compound of the general formula (I) or a pharmaceutically acceptable salt thereof. The present invention also relates to use of a compound of the general formula (I) or a pharmaceutically acceptable salt thereof in preparing a medicament for treating a disease resulted from an abnormality in acetylcholinesterase activity. 

Donepezil derivative and use thereof

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Nanjing, China

Cuixia Zhang