Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Euroapi Hungary Limited Liability Company

Csaba Váradi

Irén Hortobágyi

Zsuzsanna Kardos

Imre Rozsumberszki

Tamás Bán

Tibor Szabó

István Lászlófi

Péter Buzder-Lantos

Imre Juhász

Ágnes Nagyné Borkó

László Fónagy

The present invention relates to a process for the preparation of iloprost of formula I through new intermediates, isolation of iloprost of formula I in solid form, as well as preparation of the 16(S)-iloprost and 16(R)-iloprost isomers of formulae (S)-I and (R)-I and isolation of iloprost of formula I and 16(S)-iloprost of formula (S)-I in solid, crystalline form.

Process for the preparation of iloprost

The present invention relates to a process for the preparation of iloprost of formula I through new intermediates, isolation of iloprost of formula I in solid form, as well as preparation of the 16(S)-iloprost and 16(R)-iloprost isomers of formulae (S)-I and (R)-I and isolation of iloprost of formula I and 16(S)-iloprost of formula (S)-I in solid, crystalline form. 

The subject of the invention is a novel process for the preparation of Carboprost tromethamine salt where alkylation the enone of the general formula (II) is carried out in the presence of a chiral auxiliary in aprotic solvent with a Grignard reagent. The methyl ester epimers of formula (VII) are separated by gravity silica gel chromatography and the salt formation is carried out by using solid tromethamine base. 

Process for the preparation of carboprost and its tromethamine salt

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