Richter Gedeon Vegyeszeti Gyar Rt

Csaba Kuthi

Laszlo Szporny

Egon Karpati

Csaba Szantay

Bela Kiss

Elemer Ezer

Judit Matuz

Zsolt Szombathelyi

Katalin Csomor

Lilla Forgacs

Kalman Harsanyi

Bela Hegedus

Erzsebet Lapis

Ferenc Trischler

Istvan Laszlovszky

Aniko Gere

Eszter Cholnoky

Maria Incze

Ferenc Soti

Zsuzsanna Balogh Nee Kardos

Gyorgy Hajos

Lajos Szabo

Gyorgy Kalaus

Bela Stefko

Janos Kreidl

Laszlo Czibula

Maria Farkas Nee Kirjak

Gyorgy Visky

Marta Kapolnas Nee Pap

Anna Kallay Nee Sohonyai

Hajnalka Vikar Nee Petho

Hajnalka V Petho

Anna Kallay

Marta Kapolnas

The invention relates to new racemic and optically active 1,12b-disubstituted octahydroindolo[2,3-a]quinolizine derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and represent hydrogen, halogen, nitro, alkyl having from 1 to 6 carbon atoms, alkoxy having from 1 to 6 carbon atoms or hydroxyl,

1,12-disubstituted octahydroindolo[2,3-]quinolizine derivatives,

The invention relates to the preparation of cis and trans stereoisomers of racemic and optically active eburnamenine derivatives of the general formula (Ia) ##STR1## or (Ib), ##STR2## wherein R.sub.1 stands for a C.sub.1-4 alkyl group; and

Eburnamenine derivatives, pharmaceutical compositions and methods

The invention relates to the new (-)-1.beta.-ethyl-1.alpha.-hydroxymethyl-1,2, 3,4,6,7,12,12b.alpha.-octa-hydroindolo[2,3-a] quinolizine of the formula (I) ##STR1## and acid addition salts thereof. According to another aspect of the invention there is provided a process for the preparation of the compound of formula (I) and acid addition salts thereof by resolution of the corresponding racemic compound and optionally by subsequent hydrolysis and/or salt formation. The compound of formula (I) shows a remarkable peripheral vasodilating and antihypoxial activity. Pharmaceutical compositions comprising it as active ingredient are also within the scope of the invention.

(-)-1.beta.-ethyl-1.alpha.-hydroxymethyl-1,2,3,4,6,7,12,

The invention relates to new 1,2,3,4,6,7,12,12b-octahydroindolo[2,3,-a]quinolizin-1-yl-alkanecarboxylic acid amides of the formula (I), ##STR1## wherein R.sub.1 and R.sub.2 stand independently for a hydrogen or halogen atom, or a hydroxyl, nitro or C.sub.1-4 alkoxy group;

Octahydroindolo[2,3-a]quinolizin-1-yl-alkanecarboxylic acid amines and

The invention relates to new 2-pyridine-thiol derivatives of the formula (I), ##STR1## wherein R is hydrogen or alkyl having from 1 to 4 carbon atoms,

Certain 3- or 4-benzoyl-2-[(2-aminoethyl)thio-pyridines] and their

The compound N-{2-[(3-benzoyl-1-pyridyl)-thio]-ethyl}-N'-cyano-S-methyl-isothiourea and pharmaceutically acceptable acid addition salts thereof are disclosed as well as pharmaceutical compositions containing same and a method of treatment employing same. The compound or its acid addition salts are effective in treating gastric oedema and thus are useful in ulcer therapy.

N-{2-[(3-benzoyl-2-pyridyl)-thio]-ethyl}-N'-cyano-S-methyl-isothiourea,

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Budapest, Hungary

Csaba Kuthi