Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Egyt Gyogyszervegyeszeti Gyar

Csaba Kiss

Sandor Virag

Agoston David

Gabor Nagy

Ivan Beck

Tibor Horvath

Jozsef Rakoczi

Kalman Simon

Miklos Nemes

Agnes Udvardi

Ilona Simonidesz Nee Vermes

Imre Horvath

The invention relates to stabilized, prostaglandin-containing tablets with controlled rate of solubility, for local use and a process for the preparation thereof. The tablets according to the invention comprise 0.2 to 20% by weight of one or more natural or synthetic prostaglandins, 0.4 to 40% by weight of a non-toxic buffer, which adjusts the pH of the liquid film formed on the surface of the solid phase due to air humidity, to 3 to 5, 1 to 50% by weight of stearic acid, 0 to 15% by weight of an alkali earth metal stearate, 10 to 95% by weight of lactose and/or mannite, 0 to 15% by weight of a further granulation aid, 1 to 30% by weight of a disintegrating agent and optionally 0.5 to 10% by weight of a flavoring and aroma substance and are prepared under a pressure of 500 to 2000 kp./cm.sup.2. (49.03 to 196.13 MPa).

Stabilized, prostaglandin-containing tablets with controlled rate of

The invention relates to a novel process for preparing 2-guanidinomethyl-perhydroazocine-sulfate of formula I ##STR1## comprising the steps of catalytically reducing the 2-nitromethylene-perhydroazocine of formula IV ##STR2## in solution in acetone at a temperature of 20.degree. to 50.degree. C, treating the separated reaction product with an aqueous mineral acid and then reacting it with S-methyl-isothiocarbamid-sulfate. The process gives the desired end-product of formula I also on industrial scales.

Process for preparing 2-guanidinomethyl-perhydroazocine-sulfate

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Csaba Kiss