Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Astra Aktiebolag

Aktiebolaget Astra

Csaba Gonczi

Dezso Korbonits

Pal Kiss

Gergely Heja

Endre Palosi

Ida Szvoboda Nee Kanzel

Maria Szomor Nee Wundele

Laszlo Ledniczky

Judit Kun

Gabor T Szabo

Tamas U Kallay

Judit Cser Nee Kun

Gabor Kovacs

Csaba Huszar

Karoly Horvath

Erzsebet Molnar Nee Bako

Attila Nemeth

Erzsebet Szalay

Vera Kovacs Nee Mindler

Istvan Bone

Ferenc Sperber

Karoly Ban

Ferenc Morasz

Livia Nagy Nee Koranyi

Erzsebet Szabo Nee Kardos

Gyorgy Mihalovics

Karol Gyure

Sandor Garaczy

Sandor Virag

Gyula Sebestyen

Tamas Szuts

Emil Minker

Ildiko Buttkai

Arpad Kvari

Peter Gyri

Mihaly Sut

Mihaly Su

Peter Gy Ri

Ida Szvoboda Nee Kauzel

Gyorgy Kormoczi

Andras Kelemen

Arpad K Vari

Iidiko Buttkai

Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and

The present invention relates to a process for the preparation of compounds of general formula (I), wherein R stands for a straight chained C.sub.1-5 alkyl group substituted by a chlorine atom in the 2-position, and acid addition salts thereof, characterized by reacting a 3,5-dichloro-2-alkanone of general formula (V), wherein R is a defined above, with an inorganic thiocyamate, and a) converting the 3-thiocyanato-5-chloro-2-alkanone of general formula (IV), thus obtained, wherein R is as defined above, into 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II), wherein R is as defined above, by gaseous hydrochloric acid in an organic solvent, hydrogenating the said compound in the presence of a metal catalyst in an organic solvent, or b) reacting said compound of general formula (IV) with an aqueous mineral acid and treating the 2-hydroxy-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (III), thus obtained with a halogenating agent, and hydrogenating the 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II) thus obtained, wherein R is as defined above, in an organic solvent in presence of a metal catalyst, and optionally converting the 4-methyl-5-(2-chloroalkyl)-thiazole of general formula (I), wherein R is as defined above, thus obtained or a hydrochloride salt thereof, in a manner known per into another acid addition salt or setting free a compound of general formula (I), wherein R is a defined above, from its acid addition salt.

The invention relates to a process for the preparation of compounds of formula (I) ##STR1## wherein R.sup.1 stands for hydrogen or the group COR.sup.2, wherein

Process for the preparation of diphenyl ether derivatives

A process is disclosed for the preparation of a compound of the formula (XI) ##STR1## or a salt thereof, wherein R.sup.1 is hydrogen, halogen, C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.3 alkoxy, or trifluoromethyl;

Process for the preparation of 5(6)-thio substituted benzimidazoles

Antitussive compounds of the formula I ##STR1## or physiologically acceptable acid addition salts thereof are disclosed, where A stands for straight or branched chain C.sub.1-5 alkylene or ##STR2## R.sub.1 stands for straight or branched chain C.sub.1-10 alkyl, halogenoalkyl, hydroxyalkyl, C.sub.5-6 cycloalkyl, vinyl, 2-ethoxyethyl, carbonylalkyl or aminoalkyl of the formula ##STR3## wherein R stands for hydrogen or methyl, n is 0 to 3,

Theophyllinyl-alkyl-oxadiazoles, process for the preparation thereof and

A new process is disclosed for the preparation of a compound of the formula (VIII) ##STR1## wherein R.sup.1 is hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-3 alkoxy, or trifluoromethyl;

Production of thiocyanato benzimidazoles

2-(3-Phenoxy-phenyl)-propionic acid or its pharmaceutical treatments, are prepared by hydrolyzing and partially decarboxylating ##STR1## wherein R=C.sub.1 -C.sub.6 alkyl or amino, the latter compounds being themselves new and, where R=C.sub.1 -C.sub.6 alkyl, have antiinflammatory pharmaceutical properties.

Process for the preparation of 2-(3-phenoxy-phenyl)-propionic acid

3-Phenoxybenzene derivatives are prepared by a method which comprises the steps of(a) chlorinating benzaldehyde with chlorine gas in the presence of a hydrocarbon and a Lewis acid catalyst to obtain 3-chlorobenzaldehyde; (b) reacting the 3-chlorobenzaldehyde with ethylene glycol to obtain 2-(3-chlorophenyl)-1,3-dioxolane; (c) etherifying said dioxolane with an alkali phenolate to yield the intermediate 2-(3-phenoxyphenyl)-1,3-dioxolane and converting this intermediate to the corresponding aldehyde, cyanohydrin, sulfonic acid salt or oxime derivative.

Process for the preparation of 3-phenoxybenzenes

A process for the preparation of anthelmintic compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen or --COOR;

Sulfur-containing benzimidazole derivatives

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Csaba Gonczi