Novartis Ag

Crystal Byers

Chandra Vargeese

Rohan Eric John Beckwith

Thomas Zabawa

Ritesh Bhanudasji Tichkule

Gabriel Grant Gamber

Jeremy Lee Baryza

Keith Bowman

Tanzina Fazal

Cameron Chuck-munn Lee

Junping Zhao

Shuangxi Wang

Laura Ellen West

Cameron Chuck-Munn Lee

This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

Lipids and lipid compositions for the delivery of active agents

This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R-R, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

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Cambridge, MA, United States of America

Crystal Byers