Millipore Corporation

Other

Genentech, Inc.

Pall Corporation

Cristopher J Petersen

Steven R Pearl

Wayne S Merrill

Bradley Wolk

Boris Pesakovich

Cheryl Sayer

Leo Karmiy

Cheryl A Sayer

A manifold plate and a filtration arrangement including a manifold plate which comprises a body having a mounting region on the exterior of the body and first and second fluid channels extending within the body. The mounting region has at least one first opening and at least one second opening. At least one first fluid passageway fluidly couples the first opening to the first fluid channel and at least one second passageway fluidly couples the second opening to the second fluid channel. One or more filtration units may be mounted to the mounting region in fluid communication with the first and second openings of the manifold plate.

Manifold plates and fluid treatment arrangements including manifold plates

An automated process development device providing flexibility and accuracy for the investigative development of tangential flow filtration (tff) processes and used for evaluating the process parameters of a laboratory scale tff process with an eye towards developing a commercial scale process. The device&#x2014;operable to a recirculation volume of less than 20 milliliters&#x2014;includes: a reservoir having a distinct mixing zone; a tff module; conduits defining a fluid process stream through which a liquid sample is recirculated; pumps for driving and valves for regulating the flow of the liquid sample through the stream; sensors for acquiring data about the sample as it flows through the stream; and an electronic data processing network capable of receiving, transmitting, processing, and recording data associated with the operation of the pumps, valves, and sensors, the recorded data being sufficiently comprehensive to determine the conduct of the tangential flow filtration process at a substantially larger scale.

Automated low-volume tangential flow filtration process development device

The present invention provides an operation editor that includes a user interface for programming operations to be performed by a chemical process machine. Through the user interface the user may specify that one or more of the steps in an operation be variable. Such variable steps may subsequently be edited by the same or another user when the operation is incorporated into a procedure. Steps in the operation that are not variable are fixed and may not be edited when the operation has been incorporated into a procedure. Furthermore, individual fields in a variable step may be either variable or fixed. The present invention also provides a procedure editor that includes a user interface, which allows the user to edit variable steps within the procedure's operations. The procedure editor presents to the user for editing only those steps within the procedure that are variable.

Chemical process machine programming system

A filtration apparatus is provided which is formed from multilayer presealed elements and monolayer elements that are insert molded together. The device is provided with a feed port, a filtrate port and, optionally, a retentate port. The sealing configuration of the presealed elements and the seal provided by the insert molding step effect a seal configuration that causes a feed liquid to be filtered to form a filtrate such that the filtrate is not mixed with either the feed or a retentate.

Process for forming a membrane filtration apparatus

A tangential flow filtration apparatus is provided which includes a liquid feed reservoir and a tangential flow filtration module connected together by manifolds. The manifolds eliminate the need for tubular conduits, thereby effecting a reduction in recirculation volume for the apparatus.

Tangential flow filtration apparatus

A filtration apparatus for deadend filtration is provided which is formed from multilayer presealed elements and monolayer elements that are insert molded together. The device is provided with a feed port, and a filtrate port. The sealing configuration of the presealed elements and the seal provided by the insert molding step effect a seal configuration that causes a feed liquid to be filtered to form a filtrate such that the filtrate is not mixed with the feed.

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Amherst, NH, United States of America

Cristopher J Petersen