Inv Nylon Chemicals Americas, LLC

Cristina Serrano Amatriain

Paul S Pearlman

Alexander Brett Foster

Gary J Smith

Mark Paul Taylor

Jonathan Paul Combe

Daniel Bawdon

Provided herein are methods for increasing the yield of an extracellular product synthesized by an organism cultured in a continuous aerobic fermentation system. The extracellular product yield is increased through the use of an organism modified to decreased production of polyhydroxyalkanoate, to increase production of the extracellular product, and to include promoters that can be inducible in response to nutrient limitation conditions. The extracellular product yield is also increased by operating the continuous fermentation system under particular nutrient limitation conditions. Also provided are non-naturally occurring organisms that have been modified for use with the provided methods, and extracellular products made using the provided methods.

Materials and methods for controlling limitation conditions in product biosynthesis for non-PHB generating species of the generaorand organisms related thereto

Provided herein are methods for generating cellular biomass in continuous aerobic fermentation systems. The biomass yield, and the concentration of polyhydroxyalkanoate within the biomass, are each directed to advantageous levels by operating the continuous fermentation system under particular nutrient limitation conditions. Also provided are biomass produced using the provided methods, and animal feed compositions including the provided biomass.

Materials and methods for controlling PHA biosynthesis in PHA-generating species of the generaorand organisms related thereto

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Redcar, United Kingdom

Cristina Serrano Amatriain