Farmabios S.p.a.

Farmabios S.p.s.

Cristina Manfrotto

Claudio Gianluca Pozzoli

Maurizio Velati

Marco Brusasca

Andrea Busca

Enrico Torregrossa

Marco Nicolini

Mario Di Giacomo

Mauro Gaboardi

A method for the purification of allopregnanolone is disclosed. Allopregnanolone prepared from isopregnanolone contains impurities such as triphenylphosphine oxide and other unknown impurities. To remove these impurities and purify allopregnanolone, the allopregananolone is dissolved in acetonitrile, and crystallized from the acetonitrile. The resulting crystallized allopregnanolone may then be re-crystallized from acetonitrile to further purify the allopregnanolone.

Process for the preparation of allopregnanolone

A process for preparing the [R&#x2014;[R*,R*-(E)]]-2,2'-(1,8-dioxo-4-octene-1,8-diyl) bis(oxy-3,1-propanediyl)bis(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl) methyl]isoquinolinium) dichloride, commonly known as mivacurium chloride, useful as short-duration neuromuscular blocking agent.

Process for the preparation of mivacurium chloride

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Gropello Cairoli, Italy

Cristina Manfrotto