Pharmacia & Upjohn

Farmitalia Carlo Erba S.r.l.

Cristina Geroni

Antonino Suarato

Michele Caruso

Marina Ripamonti

Nicola Mongelli

Alberto Bargiotti

Nuccia Oneto

There are provided the combined use of 4-demethoxy-3&prime;-deamino-3&prime;-aziridinyl-4&prime;-methansulfonyl daunorubicin or 4-demethoxy-N,N-bis(2-chloroethyl)-4&prime;-methansulfonyl daunorubicin and an anti-neoplastic anti-mitotic compound and/or a platinum derivative in the treatment of tumors, as well as in the prevention or treatment of metastasis or in the treatment of tumors by inhibition of angiogenesis.

Anti-tumor synergetic composition

The combination of 4-demethoxy-3&prime;-deamino-3&prime;-aziridinyl-4&prime;-methansulfonyl daunorubicin or 4-demethoxy-N,N-bis(2-chloroethyl)-4&prime;-methansulfonyl daunorubicin together with an antineoplastic topoisomerase I inhibitor yields preparations exhibiting anti-cancer effects. These preparations can be used in the treatment of tumors and especially 4-demethoxy-3&prime;-deamino-3&prime;-aziridinyl-4&prime;-methansulfonyl daunorubicin in the treatment of brain tumors.

Antitumor composition containing a synergistic combination of an anthracycline derivative with a camptothecin derivate

The present invention relates to 3-deoxy-derivatives of D-mannosamine of formula ##STR1## wherein R is --NH.sub.2 or a C.sub.2 -.sub.5 alkanoyl-NH-- or CF.sub.3 CONH-- group; each of R.sub.1 and R.sub.2 independently is C.sub.1 -C.sub.4 alkyl, or R.sub.1 is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy, and R.sub.2 is hydrogen or both of R.sub.1 and R.sub.2 are fluorine; and wherein, when R.sub.1 is methoxy and R.sub.2 is hydrogen then R is other than --NH.sub.2, or a pharmaceutically acceptable salt thereof, which are useful as angiogenesis inhibitors, in particular as development of metastasis inhibitors.

3-deoxy-mannosamine derivatives

Growing community of inventors

Milan, Italy

Cristina Geroni