Janssen Pharmaceuticals, Inc.

Cristhina Kellen Fae

Jeroen Geurtsen

Jan Grijpstra

Marleen Eveline Weerdenburg

Jakob Louris Feitsma

Polypeptides comprising a FimH lectin domain comprising at least one an amino acid mutation that causes the FimH lectin domain to be in the low affinity conformation for mannose are described. Pharmaceutical compositions which comprise such polypeptides and methods of stimulating an immune response in a subject in need thereof by administration of the polypeptide are further described.

FimH mutants, compositions therewith and use thereof

Polypeptides comprising a FimH lectin domain comprising an amino acid mutation that causes the FimH lectin domain to be in the low affinity conformation for mannose are described. Pharmaceutical compositions which comprise such polypeptides and methods of stimulating an immune response in a subject in need thereof by administration of the polypeptide are further described.

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Oegstgeest, Netherlands

Cristhina Kellen Fae