Wista Laboratories Ltd.

Craig Williamson

John Mervyn David Storey

Colin Marshall

Claude Michel Wischik

James Peter Sinclair

Charles Robert Harrington

Janet Elizabeth Rickard

David Horsley

Thomas Craven Baddeley

Scott Clunas

Karrar Ahmad Khan

Christopher Paul Larch

Michael Simpson

Ahtsham Ishaq

Barry Alan Wood

Yin Sze Loh

Steven John Kemp

John Mervyn Storey

Michel Wischik Claude

Disclosed are compounds of general formula (I): and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.

Phenothiazine diaminium salts and their use

The invention relates to compounds of general formula (I): wherein: each of Rand Ris independently selected from: &#x2014;H, Calkyl, Calkenyl, and halogenated Calkyl; each of Rand Ris independently selected from: &#x2014;H, Calkyl, Calkenyl, and halogenated Calkyl; each of R7NA and R7NB is independently selected from: &#x2014;H, Calkyl, Calkenyl, and halogenated Calkyl; and wherein: each of Rand Ris independently selected from: Calkyl, halogenated Calkyl, and Caryl; or Rand Rare linked to form a group selected from: Calkylene and Carylene; and pharmaceutically acceptable salts thereof, which are useful in the treatment of, for example, Alzheimer's disease. In other aspects the invention also relates to novel formulations of 3,7-diamino-10H-phenothiazinium salts. 

The present invention pertains generally to methods of preparing certain 9-(arylalkyl)-1,2,3,4-tetrahydro-&#x3b3;-carboline compounds and their analogues, and especially to methods of preparing dimebon. The present invention also pertains to methods of preparing certain intermediate compounds which find use in the synthesis of the 9-(arylalkyl)-1,2,3,4-tetrahydro-&#x3b3;-carboline compounds.

Synthesis of 9-(arylalkyl)-1,2,3,4-tetrahydro-&#x3b3;-carboline and analogues and intermediates

Described are methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as 'diaminophenothiazinium compounds') including Methylhioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: a thiosulfonic acid formation (TSAF); an oxidative coupling (OC); and a ring closure (RC). Also described are resulting compounds and compositions comprising them (e.g., tablets, capsules) for use in methods of medical treatment and diagnosis, etc., for example, for tauopathies, or Alzheimer's disease (AD). 

Methods of chemical synthesis of diaminophenothiazinium compounds involving the use of persulfate oxidants

Growing community of inventors

Guildford, United Kingdom

Craig Williamson