Amgen Inc.

Craig Tomooka

Jay Patrick Powers

Daqing Sun

Zhulun Wang

Sarah Elizabeth Lively

Andrew Smith

Alexander David Frenkel

Juan Carlos Jaen

Francisco Xavier Talamas

Timothy David Cushing

Xiaolin Hao

Marc Labelle

Sharada Shenvi Labadie

Xiao He

David Louis Clark

Michael R Degraffenreid

Marie-Louise Smith

Nigel P C Walker

Adrian L Gill

Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related conditions or disorders. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, immune response regulation and cell proliferation. The subject compounds are 2-amino-imidazole derivatives.

Benzimidazole derivatives

Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain quinoline or quinazoline rings.

Inflammation modulators

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San Mateo, CA, United States of America

Craig Tomooka