Apotex Pharmachem Inc.

Apotex Inc.

Craig Stewart

Yajun Zhao

Gamini Weeratunga

Uma Kotipalli

Peter Garth Blazecka

Michael B Johansen

Probal Kanti Datta

Sammy Chris Duncan

Murali Kondamreddy

Nalini Nagireddy

The present invention provides processes for the preparation of Tasimelteon (1), as well as processes for the preparation of intermediates of Formulas (2), (3) and (4) useful in the preparation of Tasimelteon (1). 

Processes for the preparation of Tasimelteon and intermediates thereof

This invention provides processes for preparation of 3-alkyl indoles of Formula 1: wherein A, Aand Aare independently selected from the group consisting of: H, X, OR, CN, CONRand C0R; Ris C-Calkyl; Ris H or C-Calkyl; Ris C-Calkyl; LG is a leaving group; X is a halogen; and n is 1, 2 or 3.

Processes for the preparation of 3-alkyl indoles

This invention relates to 1,3-oxathiolane derivatives (I), processes for the preparation of 1,3-oxathiolane derivatives and intermediate compounds thereof. 

1,3-Oxathiolane derivatives, process for the preparation of 1,3-Oxathiolane derivatives and intermediates thereof

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Edmonton, Canada

Craig Stewart