Other

University of Utah Research Foundation

Cognetix, Inc.

Craig S Walker

Baldomero M Olivera

Reshma Shetty

Robert M Jones

Lourdes J Cruz

Maren Watkins

David M Hooper

Elsie C Jimenez

Gregory S Shen

Richard Jacobsen

Clark Colledge

Jean E Rivier

J Michael McIntosh

David R Hillyard

R Tyler McCabe

Richard T Layer

Li-Ming Zhou

Alma L Burlingame

Julita S Imperial

Michael Fainzilber

Pradip K Bandyopadhyay

Doug Steel

Doug Steele

Buzz Day

Karel S Kits

Fe C Abogadie

An inflatable tent assembly includes a trailer has a pair of wheels, a hitch and a body. The body has a plurality of storage compartments therein. The body has a front end, a back end, a first lateral side and a second lateral side. A generator is coupled to the trailer and the generator is positioned on the body. A blower is positioned in the trailer and the blower is positioned on the body. A tent is removably contained within the tent compartment and the tent is positionable on a support surface. The tent is selectively operationally coupled to the blower such that the blower inflates the tent into a standing position. Thus, the tent may be occupied.

Inflatable tent assembly

The invention relates to relatively short peptides (termed &#x3c4;-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.

&#x3c4;-conotoxin peptides

The invention relates to relatively short peptides (termed I-conotoxins herein), about 30-50 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include four disulfide bonds.

I-superfamily conotoxins

The invention relates to relatively short peptides (termed &tgr;-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.

Tau-conotoxin peptides

This invention relates to relatively short peptides about 25-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogs to the naturally available peptides, and which include three cyclizing disulfide linkages and one or more &ggr;-carboxyglutamate residues. More specifically, the present invention is directed to &ggr;-conopeptides having the general formula I: Xaa -Cys-Xaa -Cys-Xaa -Xaa -Cys-Cys-Xaa -Cys-Xaa -Cys-Xaa (SEQ ID NO:1), as described herein; or having the general formula II: Xaa -Cys-Xaa -Cys-Xaa -Xaa -Cys-Cys-Xaa -Xaa -Cys-Xaa -Cys-Xaa (SEQ ID NO:2), as defined herein; or having the general formula III: Xaa -Cys-Xaa -Cys-Xaa -Xaa -Xaa -Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa -Cys-Xaa (SEQ ID NO:3), as described herein; or having the general formula IV: Xaa -Cys-Xaa -Cys-Xaa -Xaa -Xaa -Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa -Cys-Xaa (SEQ ID NO:4), as described herein; or having the general formula V: Xaa -Xaa -Cys-Xaa -Xaa -Phe-Xaa -Cys-Thr-Xaa -Ser-Xaa -Cys-Cys-Ser-Asn-Ser-Cys-Asp-Gln-Thr-Tyr-Cys-Xaa -Leu-Xaa (SEQ ID NO:5), as described herein. The invention further relates to specific &ggr;-conopeptides, specific pro-&ggr;-conopeptides and nucleic acids encoding the pro-&ggr;-conopeptides. The invention also includes pharmaceutically acceptable salts of the conopeptides. These conopeptides are useful as agonists of neuronal pacemaker calcium channels.

Gamma-conopeptides

The present invention is directed to conantokin peptides, conantokin peptide derivatives and conantokin peptide chimeras, referred to collectively as conantokins, having 10-30 amino acids, including preferably two or more &ggr;-carboxyglutamic acid residues. The conantokins are useful for the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, neuroprotective agents or analgesic agents.

Conantokins

The present invention is relates to a method for purifying a &ggr;-carboxylase from Conus snails and to a method for assaying the activity of this &ggr;-glutamyl carboxylase.

Methods for purifying and assaying a conus &ggr;-carboxylase

Growing community of inventors

Salt Lake City, UT, United States of America

Craig S Walker