Gilead Sciences, Inc.

Craig S Gibbs

Richard L Mackman

William John Watkins

Hyung-Jung Pyun

Aesop Cho

Peter H Nelson

Jennifer R Zhang

Thorsten A Kirschberg

Adrian S Ray

James Ming Chen

Kuei-Ying Lin

David A Oare

Lee Shun Chong

Sundaramoorthi Swaminathan

Maria Fardis

Carina E Cannizzaro

Xiaowu Chen

Christopher P Lee

Ralph F Hirschmann

Rosemarie Sherlock

Manuel Tsiang

Choung U Kim

Manoj C Desai

William A Lee

Haolun Jin

Lijun Zhang

Constantine G Boojamra

Alan X Huang

David Y Markevitch

Steven H Krawczyk

Vidya K Prasad

Lawrence L K Leung

Lawrence L Leung

The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.

Therapeutic phosphonate compounds

The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Anti-inflammatory phosphonate compounds

Novel polypeptides (NPs) are provided which are capable of protein C activation without significant fibrinogen clotting activity, and vice versa. NPs having enhanced protein C activating properties in relation to fibrinogen clotting are useful in particular as anticoagulants and in screening for substances that agonize or antagonize this property and in diagnostic procedures to determine the status of patients' activated protein C-mediated anticoagulant pathway. Procoagulant NPs are useful to promote clotting in the course of therapy of solid tumors, as an impregnate for bandages, or in diagnostic assays. The NPs are produced in recombinant cell culture or by in vitro methods.

Polypeptides and coagulation therapy

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Palo Alto, CA, United States of America

Craig S Gibbs