Janssen Pharmaceutica Nv

Leonard, Kristi A.

Craig R Woods

David A Kummer

Rachel T Nishimura

Ronald L Wolin

Hariharan Venkatesan

Xiaohua Xue

James Patrick Edwards

Aihua Wang

Kevin Douglas Kreutter

Kristi A Leonard

Maud J Urbanski

Umar Maharoof

Kent Barbay

Maxwell David Cummings

Anne Fourie

Steven D Goldberg

Virginia M Tanis

Connor L Martin

Kelly J McClure

Elizabeth G Fennema

Steven P Meduna

William Moore Jones

Stefan McCarver

Alexander Valdes

Alexander Raymond Rovira

Timothy B Rhorer

Steven Loskot

Douglas Behenna

John M Keith

Alec D Lebsack

Charlotte Pooley Deckhut

Taraneh Mirzadegan

Joan M Pierce

Kelly Ganamet

Kelly Mcclure

Joan Pierce

Kelly Lynn Ganamet

Alexander Rovira

Anne M Fourie

The present application discloses compounds having the following formula: or pharmaceutically acceptable salts thereof, wherein R, R, R, Rand Rare defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.

Imidazopyridazines as modulators of IL-17

The present invention comprises compounds of Formula I. wherein:R, R, R, R, R, R, R, Q, and Qare defined in the specification. The invention also comprises a method of treating or ameliorating a ROR-&#x3b3;-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating ROR&#x3b3;t activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

Phenyl and pyridinyl substituted imidazoles as modulators of ROR&#x3b3;T

The present invention comprises compounds of Formula I. wherein: The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein the syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR&#x3b3;t activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

6-aminopyridin-3-yl thiazoles as modulators of ROR&#x3b3;T

The present invention comprises compounds of Formula I. wherein:R, R, R, R, R, R, R, and Q are defined in the specification. The invention also comprises a method of treating or ameliorating a ROR-&#x3b3;-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating ROR&#x3b3;t activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

Phenyl substituted pyrazoles as modulators of ROR&#x3b3;t

The present invention comprises compounds of Formula I. wherein:R, R, R, R, R, R, R, R, and Rare defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR&#x3b3;t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim

Alkyl linked quinolinyl modulators of ROR&#x3b3;t

Phenyl linked quinolinyl modulators of ROR&#x3b3;t

The present invention comprises compounds of Formula I. wherein: The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR&#x3b3;t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim

Quinolinyl modulators of ROR&#x3b3;t

The present invention comprises compounds of Formula I.  The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR&#x3b3;t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim

Heteroaryl linked quinolinyl modulators of RORgammat

Heteroaryl linked quinolinyl modulators of ROR&#x3b3;t

Methylene linked quinolinyl modulators of ROR&#x3b3;t

Growing community of inventors

San Diego, CA, United States of America

Craig R Woods