National Institutes of Health, a Component of the US Dept. of Health & Human Services

Van Andel Research Institute

Craig P Webb

Stephen H Leppla

Nicholas S Duesbery

George Vande Woude

George F Vande Woude

Andrej Bugrim

A system and method for performing a research and analysis in the bioinformatics field which associates data from a variety of experimental platforms with preclinical and/or clinical samples and subjects. The system and method allows for the analysis of data stored therein received from a variety of experimental platforms, as well as association with preclinical and clinical sources. A fully integrated medical informatics/molecular bioinformatics database/analysis package is provided herein suitable for accelerated target discovery, diagnosis, and treatments for molecular-based diseases. An identified relationship is used with a computational distribution for scoring nodes in a network built from a set of experimentally-derived condition-specific genomic or proteomic profiles for the development of new treatments, diagnoses, biomarker identification, or target identification. The biomedical research tool provides for multi-directional data directionality that allows for detailed genotype to phenotype analysis for the evaluation of new drugs and treatments.

Bioinformatics research and analysis system and methods associated therewith

The present invention relates to in vitro and ex vivo methods of screening for modulators, homologues, and mimetics of lethal factor mitogen activated protein kinase kinase (MAPKK) protease activity, as well as methods of treating cancer by administering LF to transformed cells.

Anthrax lethal factor is a MAPK kinase protease

Anthrax lethal factor is a mapk kinase protease

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Rockford, MI, United States of America

Craig P Webb