St. Jude Medical, Cardiology Division, Inc.

Pacesetter, Inc.

Craig Markovitz

Cyrille Casset

Louis-Philippe Richer

Chunlan Jiang

Jan O Mangual-Soto

Jan Mangual

Stuart Rosenberg

Luke C McSpadden

The present disclosure provides systems and methods for optimizing pacing parameters of a cardiac pacing device implanted in a patient. The systems and methods measure a plurality of hemodynamic responses of the patient. Each hemodynamic response is associated with the cardiac pacing device configured with one candidate pacing parameter set of a plurality of candidate pacing parameter sets. Each candidate pacing parameter set is classified as electrically equivalent to a reference pacing parameter set according to a classification criterion. The systems and methods further identify an optimal hemodynamic response from the plurality of hemodynamic responses, and select a final candidate pacing parameter set corresponding to the optimal hemodynamic response.

Systems and methods for normalizing cardiac electrical conditions of measured hemodynamic variations for use in cardiac pacing device optimization processes

The signal quality of an electrophysiological signal can be determined from information regarding proximal stability of an electrophysiology catheter at the time the signal is acquired and temporal stability of the electrophysiological signal. The proximal stability information can include a distance between the electrophysiology catheter and an anatomical surface, a velocity of the electrophysiology catheter, and/or contact force between the electrophysiology catheter and the anatomical surface. Graphical representations of signal quality scores can be output to a display in order to enable visualization thereof by a practitioner.

System and method for electrophysiological mapping

Systems and methods for identifying potential ablation sites using electrical parameter data are provided. A method includes geometrically isolating an arrhythmogenic substrate in a three-dimensional geometry. The method further includes generating a first cumulative map from a first dataset including electrical parameter data for each vertex in the isolated arrhythmogenic substrate, and generating a second cumulative map from a second dataset including additional data for each vertex. The method further includes generating a third cumulative map from the first and second cumulative maps, and displaying the third cumulative map on the three-dimensional geometry to facilitate identifying potential ablation sites.

Systems and methods for identifying ablation locations using electrical parameter data

The present disclosure is directed to merging data acquired from differently configured catheters on a common map. In use, physical characteristics of catheters influence recorded electrical signals/responses such that differently configured catheters (e.g., different electrode sizes, shapes, materials, spacings, etc.) may record different responses to measurements taken at the same location in response to the same excitation signal. To allow merging of data from differently configured catheters in a common map, the present disclosure applies a corrective coefficient or transfer function to the recorded electrical signals of one or both catheters to counter-balance variable influences of catheter specific characteristics on recorded signals.

Methods and tools to merge mapping data acquired from multiple catheters

Systems and methods for resolving catheter rendering issues are provided. A system includes a catheter including a plurality of electrodes and a plurality of catheter pins, each catheter pin corresponding to an associated electrode. The system further includes a mapping system communicatively coupled to the catheter, the mapping system including a pin box including a plurality of sockets, a display device configured to render the catheter, and an electronic control unit (ECU). The ECU is configured to determine that the catheter is being rendered incorrectly on the display device, determine a number of electrodes that are being rendered incorrectly on the display device, identify at least one particular electrode of the plurality of electrodes that is being rendered incorrectly on the display device, and attempt to resolve the incorrect rendering of the catheter based on the determined number of electrodes and the at least one particular electrode.

Methods and systems for resolving catheter rendering issues

Local activation times (LATs) are mapped by computing an LAT range for a plurality of electrophysiology data points, splitting the LAT range into two or more LAT sub-ranges, splitting the LAT map into a corresponding number of LAT sub-maps, and associating a mapping sub-convention (e.g., a color spectrum, grayscale, and/or pattern density range) with each of the LAT sub-maps. The mapping sub-conventions can be scaled (e.g., linearly, logarithmically) to their respective LAT sub-ranges, allowing for an overall LAT map that offers increased granularity over LAT sub-ranges of particular interest to the practitioner. The LAT sub-maps can be updated in real time as additional electrophysiology data points are collected.

System and method for mapping local activation times

A method of generating an electrophysiology map of a portion of a patient's anatomy using an electroanatomical mapping system, includes defining a plurality of inclusion criteria, collecting a plurality of electrophysiology data points, each being associated with inclusion data, and identifying those electrophysiology data points that have inclusion data satisfying the inclusion criteria. The inclusion criteria can then be automatically adjusted to drive the number of electrophysiology data points having inclusion data satisfying the inclusion criteria towards a target number. A graphical representation of the electrophysiology map can be rendered using the final set of electrophysiology data points.

System and method for generating electrophysiology maps

The present disclosure provides systems and methods for determining a proposed ablation site in a cardiac chamber. A system includes an implanted device configured to record a plurality of intracardiac electrogram (IEGM) couples, and a mapping and ablation system communicatively coupled to the implanted device. The mapping and ablation system is configured to receive the recorded plurality of IEGM couples from the implanted device, calculate a parameter for each of the plurality of IEGM couples, determine, based on the calculated parameters, an area of origin for each IEGM couple, and determine an intersection between the determined areas of origin, wherein the intersection represents the proposed ablation site in the cardiac chamber.

Systems and methods for leveraging IEGM couples to determine ablation sites

A method of mapping arrhythmic activity, such as premature ventricular contraction ('PVC') activity, using an electroanatomical mapping system includes defining at least two arrhythmia template signals. Electrophysiology data points, each including an electrophysiological signal, are collected. A morphological similarity between the electrophysiological signal and a first arrhythmia template signal is computed; if this exceeds a preset threshold, then the electrophysiology data point is added to a corresponding arrhythmia map. If it does not, a morphological similarity between the electrophysiological signal and a second arrhythmia template signal is computed. If this exceeds the preset threshold, then the electrophysiology data point is added to a corresponding arrhythmia map. If neither exceeds the preset threshold, then the electrophysiology data point can be used to establish an additional arrhythmia map by defining an additional arrhythmia template signal.

System and method for generating premature ventricular contraction electrophysiology maps

A method of generating an electrophysiology map of a portion of a patient's anatomy includes receiving a plurality of electrophysiology data points, each including an associated electrophysiological signal. A template electrophysiology data point and one or more unwanted electrophysiology data points are selected from the plurality of electrophysiology data points. The electrophysiological signal associated with the template electrophysiology data point is defined as a template electrophysiological signal, while the electrophysiological signal(s) associated with the unwanted electrophysiology data point(s) is/are defined as unwanted electrophysiological signal(s). For any given electrophysiology data point, if the morphology of its associated electrophysiological signal is more similar to the morphology of an unwanted electrophysiological signal than to the morphology of the template electrophysiological signal, the given electrophysiology data point is rejected/excluded from an electrophysiology map.

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Leipzig, Germany

Craig Markovitz