Anadys Pharmaceuticals, Inc.

Scriptgen Pharmaceuticals, Inc.

Craig M Thompson

John D Bradley

C Richard Wobbe

Jeffrey B Moore

Judith M Healy

Caroline E Donnelly

David A Bailey

The invention provides novel yeast cells comprising genes whose expression can be modulated by growth in the presence or absence of metal ions, methods for making such yeast cells, and methods of using such yeast cells for determining the requirement for expression of particular genes for the growth or viability of the yeast cells. The invention also provides methods of using such yeast cells in the isolation, screening and analysis of candidate antifungal compounds.

Regulated gene expression in yeast and method of use

The invention provides novel yeast cells comprising genes whose expression can be modulated by growth in the presence or absence of metal ions, methods for making such yeast cells, and methods of using such yeast cells for determining the requirement for expression of particular genes for the growth or viability of the yeast cells.

Regulated gene expression in yeast

Disclosed herein is a purified isolated nucleic acid encoding SRB-7 (CaSRB-7) and an isolated polypeptide encoded by said nucleic acid. Also disclosed herein are vectors comprising the nucleic acid sequences, cells comprising the vectors, methods for producing the polypeptides and methods of use thereof.

Candida albicans SRB-7

Growing community of inventors

Arlington, MA, United States of America

Craig M Thompson