Intuity Medical, Inc.

Aerogen, Inc.

Simpirica Spine, Inc.

Novartis Ag

Craig M Litherland

Jeffrey L Emery

Raul Escutia

Jeffrey M Jones

Michael F Tomasco

James William Pfeiffer

Joseph P Loeffler

Raúl Escutia

Joe Maxwell

Hugues Malandain

Todd Alamin

Kelley J Lipman

Louis Calvin Fielding

Colin Cahill

Manish Kothari

Ian Bennett

Kamran Behzadian

James W Pfeiffer

Gregory Loney

Michael Albert Klimowicz

Rob Burnside

Christo P Pamichev

Joseph Maxwell

Michael A Klimowicz

Gregory C Loney

James Pfeiffer

Rual Escutia

M Jones Jeffrey

An arrangement for producing a sample of body fluid from a wound opening created in a skin surface at a sampling site includes: a housing, the housing comprising a first opening; a skin interface member disposed in the first opening, the skin interface member comprising an inner member having a second opening, and an outer member at least partially surrounding the inner member and attached to the first opening; and at least one skin-penetration member configured and arranged to project within the second opening. Arrangements having alternatively constructed skin interface members are also described.

Body fluid sampling device-sampling site interface

An arrangement for producing a sample of body fluid from a wound opening created in a skin surface at a sampling site includes at least one skin-penetration member having a first end configured to pierce the surface of the skin, and a inner lumen in communication with the first end; at least one actuator operatively associated with the at least one skin-penetration member; and at least one catalyst device configured to cause perfusion of body fluid at the sampling site; wherein the at least one actuator is configured to locate the at least one skin-penetration member so as to obstruct the wound opening while transporting body fluid through the inner lumen. Associated methods are also described.

Body fluid sampling arrangements

An arrangement includes a housing, a plurality of sampling and analysis sites contained within the housing, each of the sampling and analysis sites having a skin-penetration member having a first end configured to pierce the skin, and an inner lumen in communication with the first end, an actuator operatively associated with the skin-penetration member, and an analyte quantification member in fluid communication with the inner lumen of the skin-penetration member. Integrated devices including such arrangements are also described.

Multi-site body fluid sampling and analysis cartridge

An arrangement for producing a sample of body fluid from an opening created in a skin surface at a sampling site including a cartridge with a plurality of compartments and a plurality of sampling sites, and a detector assembly. Each sampling site includes a skin-penetration member having a first end configured to pierce the surface of the skin and an inner lumen in communication with the first end, a spring actuator operatively associated with the skin-penetration member, and a needle hub connecting the skin-penetration member and the spring actuator. The needle hub includes a reagent pad and the spring actuator is configured to drive the skin-penetration member to form the wound opening. Each compartment at least partially encloses the skin-penetration member, the spring actuator, and the needle hub of a respective sampling site.

Body fluid sampling device&#x2014;sampling site interface

Catalysts for body fluid sample extraction

A system for restricting spinal flexion includes superior and inferior tether structures joined by a pair of compliance members. Compliance members comprise tension members which apply a relatively low elastic tension on the tether structures. By placing the tether structures on or over adjacent spinous processes, flexion of a spinal segment can be controlled in order to reduce pain.

Methods and devices for controlled flexion restriction of spinal segments

Methods and systems for increasing the bending stiffness and constraining the spreading of a spinal segment

An arrangement comprises a housing containing one or more components configured for at least one of body fluid sampling and analysis. The arrangement includes a housing containing one or more components configured for at least one of body fluid sampling and analysis, and a body attachment element. The housing and the body attachment element are connected by a quick-release mechanism configured to facilitate removal of the housing from the body attachment element.

Fully integrated wearable or handheld monitor

An integrated monitoring and body fluid sampling device constructed to permit digital as well as alternate-site body fluid sampling and analysis, the device comprising: a housing; at least one skin-penetration member; and a member constructed for the application of circumferential or vacuum pressure to an appendage; wherein the member is detachably or retractably connected to the housing in a manner such that the integrated monitoring and body fluid sampling device can perform digital or alternate-site body fluid sampling and analysis. Additional arrangements and techniques are also described.

Body fluid sampling device with pivotable catalyst member

Arrangement for body fluid sample extraction

Method for body fluid sample extraction

Growing community of inventors

Cupertino, CA, United States of America

Craig M Litherland