Celgene Corporation

Celgro

Craig M Lewis

George W Matcham

Norman W Thomas

Sue L Lin

Minghua Zhang

Wei Wu

Mohit B Bhatia

Alice L Wang

Richard A Nelson

Wei Lang

Chiral fungicides and compositions containing the same are provided. Also provided are methods for using the compositions of the present invention for inhibiting the growth of fungi, including phytotoxic fungi. The use of a single isomer in treating particular plant species and against particular fungi allows for selective inhibition of fungal growth with reduced fungicidal phytotoxic effects.

Chiral imidazole fungicidal compositions and methods for their use

2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

Enzymatic synthesis of chiral amines using -2-amino propane as amine

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East Brunswick, NJ, United States of America

Craig M Lewis