Indicator Systems International, Inc.

Isi Life Sciences, Inc.

White, David

Swiss, Gerald F.

Moriarty, Robert

Keshishian, Craig

Fante, John

Pariza, Richard

Hessler, Iii, Theodore

Craig Keshishian

Robert M Moriarty

Gerald F Swiss

Richard J Pariza

David M White

John Fante

Theodore Hessler, Iii

Theordore Hessler Iii

This invention is directed to methods for the facile and accurate identification of cancer cells in a tissue sample, such as a surgical field. In particular, the compositions and methods employ conjugates comprising pro-fluorescent fluorescein based moieties bound to folic or pteroic acid targeting moiety optionally through a linker. The pro-fluorescent fluorescein based moieties are non-fluorescent but capable of being rendered fluorescent by intracellular processes. The conjugates are employed to detect cancer cells that overexpress folic acid receptors thereby providing for differential accumulation of these conjugates in these cells.

Compositions and methods for detecting cancer cells in a tissue sample

This invention relates to contact lenses comprising pH indicating moieties useful for determining the presence or absence of active bacterial infections wherein said pH indicator is entrapped in the lens. Other aspects relate to contact lenses comprising pH indicating moieties useful for determining the presence or absence of active bacterial infections and a biodegradable coating with a biocompatible colorant entrapped within the coating useful for determining the usable lifespan of the contact lens. Other aspects relate to methods of using such contact lenses.

Contact lenses with indicators

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Newport Beach, CA, United States of America

Craig Keshishian