Allied Bioscience, Inc.

Other

Srfc Bio, Inc.

Craig Grossman

Daniel A Moros

Gavri Grossman

Jie Fang

Mai Ngo

Ronald Wysocki

Misagh Alipour

Parham Asgari

Maha El-Sayed

Ingrida Grossman

Daniel Moros

Gavri Grossmann

The present disclosure provides antimicrobial coating compositions that are used to form residual antimicrobial coatings on medical implements and medical devices including the components of medical equipment such as CPAP/BiPAP machines. Antimicrobial coating compositions comprise at least one of an organosilane (RO)Si&#x2014;R&#x2014;Z, an organic amine RRRN, a titanium (IV) species, a 1,2-diol, an &#x3b1;-hydroxy acid, a &#x3b2;-hydroxy acid, and an organosilane grafted parylene polymer, wherein Ris H, alkyl, substituted alkyl, aryl or substituted aryl, Ris a bivalent linker, Z is a nucleophile, leaving group, or quaternary nitrogen substituent, and R, R, and Rare independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic.

Antimicrobial coatings for medical implements and medical devices

Aqueous antimicrobial coating compositions are disclosed comprising at least one organosilane homopolymer, present as a distribution of polymer chain lengths, and optionally at least one amine. A method of preparing an antimicrobial coating comprises coating a surface with the aqueous antimicrobial coating composition and allowing the composition to dry into a film that exhibits residual antimicrobial efficacy against microorganisms even after mechanical abrasion of the coating. The organosilane homopolymer may comprise only 3-aminopropylsilanetriol homopolymer, mixtures of 3-aminopropylsilanetriol homopolymer, 3-chloropropylsilanetriol homopolymer and 3-(trihydroxysilyl)propyl dimethyloctadecyl ammonium chloride homopolymer, or any one of various unique organosilane homopolymers having multiple amine functionality.

Antimicrobial coatings comprising organosilane homopolymers

A wet wipe is disclosed that provides both contact sanitization of a surface and application of a residual antimicrobial coating on the surface through the same wiping. The wet wipe comprises a substrate such as an absorbent nonwoven fabric and a liquid composition impregnated therein, the liquid composition comprising an organosilane such as the antimicrobial dimethyloctadecyl[3-(trimethoxysilyl)propyl] ammonium chloride, a non-silane quaternary disinfectant, an organic amine, and a solvent. The non-silane quaternary actives comprise a mixture of actives, and the solvent comprises 60 wt. % isopropanol or more.

Wet wipes comprising antimicrobial coating compositions

A method for controlling infections in a facility such as a hospital or foodservice establishment is provided. The method comprises tagging assets, monitoring asset location and pathogen contamination for each asset over time, analyzing data sets to identify which assets are the critical control points for pathogen transfer, and coating a residual self-sanitizing coating composition on each asset identified as a critical control point. The infection control method shuts down pathogen transfer routes by mitigating or eliminating pathogen growth on the critical control points.

Infection control method and system

The present disclosure provides antimicrobial coating compositions that are used to form residual antimicrobial coatings on medical implements and medical devices including the components of medical equipment such as CPAP/BiPAP machines. Antimicrobial coating compositions comprise at least one of an organosilane (RO)Si&#x2014;R&#x2014;Z, an organic amine RRRN, a titanium (IV) species, a 1,2-diol, an &#x3b1;-hydroxy acid, &#x3b2;-hydroxy acid, and an organosilane grafted parylene polymer, wherein Ris H, alkyl, substituted alkyl, aryl or substituted aryl, Ris a bivalent linker, Z is a nucleophile, leaving group, or quaternary nitrogen substituent, and R, R, and Rare independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic.

Antimicrobial coating compositions are used to form dried residual antimicrobial coatings on medical dressings including gauze, bandages, gowns and dry wipers. Antimicrobial coating compositions comprise at least one of an organosilane (RO)Si&#x2014;R&#x2014;Z, an organic amine RRRN a titanium (IV) species, a 1,2-diol, an &#x3b1;-hydroxy acid, a &#x3b2;-hydroxy acid, and an organosilane grafted parylene polymer, wherein Ris H, alkyl, substituted alkyl, aryl or substituted aryl, Ris a bivalent linker, Z is a nucleophile, leaving group, or quaternary nitrogen substituent and R, R, and Rare independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic.

Antimicrobial coatings for medical dressings and dry antimicrobial medical dressings therefrom

The present disclosure provides antimicrobial coatings on a surface comprising a reactive silanol and triethanolamine. In various examples the reactive silane is 3-chloropropylsilane triol. The coating is capable of reducing the number of Murine norovirus andinoculated on the dried coating. In various examples, the coating further comprises a mixture of peroxotitanium acid and peroxo-modified anatase sol. The compositions may be electrostatically sprayed on the surface, and in certain examples, a mixture of silanol and triethanolamine is spray-coated on the surface followed by an aqueous mixture of peroxotitanium acid and peroxo-modified anatase sol.

Antimicrobial coatings capable of reducing the number of murine norovirus inoculated thereon

An apparatus is provided for controlling hospital acquired infections by targeting critical control points for pathogen transfer. An infection control apparatus comprises an asset tagging unit; a spraying unit; a power supply unit; optionally a DNA/RNA sequencing unit; and a computing unit comprising a non-transitory computer-readable medium encoded with program instructions for controlling the asset tagging unit and the spraying unit to perform a method of infection control in the facility. In general, the apparatus is used to identify which assets are critical control points for pathogen transfer and to treat those assets with a residual self-sanitizing coating.

Infection control apparatus

A method to prepare a self-decontaminating surface, where that method includes dissolving tartaric acid in water, adding titanium (IV) isopropoxide to the tartaric acid solution to form a coating composition in water, and casting that coating composition onto a surface to form a coating having anti-microbial function.

Composition and method to form a self decontaminating surface

A method of coating a surface with an antimicrobial coating comprises spray-coating a mixture of 3-aminopropylsilane triol and triethanolamine on the surface. The coating is capable of reducing the number ofandinoculated on the dried coating. In various examples, the method further comprises the step of spray-coating a mixture of peroxotitanium acid and peroxo-modified anatase sol on the surface. The compositions may be electrostatically sprayed on the surface, and in certain examples, a mixture of silanol and triethanolamine is spray-coated on the surface followed by an aqueous mixture of peroxotitanium acid and peroxo-modified anatase sol.

Methods of coating a surface with an antimicrobial coating capable of reducing the number of murine norovirus inoculated thereon

A method of preparing an antimicrobial coating comprises coating a surface with an aqueous mixture of 3-(trihydroxysilyl)propyl dimethyloctadecyl ammonium chloride, 3-chloropropyltrimethoxysilane, and triethanolamine and then coating the surface with an aqueous titanyl sol-gel solution comprising an aqueous mixture of peroxotitanium acid and peroxo-modified anatase sol overtop of the silane to form the antimicrobial coating. The antimicrobial coating exhibits residual antimicrobial efficacy againstandafter water rinsing or after abrasion. The use of 3-chloropropyltrimethoxysilane was found to improve storage stability of the quaternary silane composition and the durability of the antimicrobial coating.

Antimicrobial coatings comprising quaternary silanes

An anti-microbial coating formulation consisting essentially of triethanolamine and a silane.

Growing community of inventors

Point Roberts, WA, United States of America

Craig Grossman