Idex Health & Science LLC

Ahntra LLC

Craig Graham

Eric Beemer

Troy Sanders

Scott Ellis

Nathaniel Nienhuis

Carl W Sims

Quan Liu

Mark Hahn

Don Pein

Scott J Ellis

Frits for use in analytical instrument systems, including liquid chromatography systems, particularly HPLC and UHPLC systems, and methods of making and using the frits, are provided. The frits can have multiple layers, which may have different surface finishes on different surfaces.

Frits for chromatography

A fluidic connection assembly and methods for quickly connecting or disconnecting a tube to a port by hand and without the use of tools. A body is adapted to receive a tube therethrough, and may have at least two sides which are hinged. Each of the hinged sides has corresponding latching portions or projections located near a lower end of the body. These projections are adapted to fit into a port or other fitting and be securely held in place. The assembly may include a tube extending through a body and through a spring located between the end of the body and the end of the tube, whereby the spring exerts a force directly or indirectly against the end of the tube and against the body, thus holding the tubing securely and sealingly engaged in the port when the assembly is connected. The body may further comprise an additional body or an adapter, and/or a cap and latch. A second spring may be used to push a projecting member into a groove or notch of an adapter when an end of the adapter is inserted into one end of the latch or the body. The fluidic connection assembly is useful in analytical instrument systems, such as for in vitro applications and/or in high pressure applications, among other things, and may be used in methods for connecting, or disconnecting, tubing or a fluidic connection assembly from a port or other fitting or connection.

Fluidic connector assembly for quick connect/disconnect

A torque limited fitting is provided having a head and a body, which in certain embodiments may be assembled by an operator. The body of the torque limited fitting has a passageway therethrough for receiving and removably holding tubing. The torque limited fitting may be adapted for use with a flat bottom port, such as in an analytical instrument, like liquid chromatography, gas chromatography, ion chromatography, or in in vitro diagnostic systems.

Torque limited fitting

A manifold assembly has a manifold and can be located between a block and a plate, and serve as a stator for a valve or other component. The manifold, block or plate can have a plurality of ports either integral thereto or removably connected thereto, with the ports adapted to receive and sealingly engage with a tube having an inner tube layer, an outer tube layer, a sleeve, a tip portion, and a nut. Each of the nut, sleeve, inner and outer tubing layers, and tip portion have a passageway therethrough, with at least the passageways in the sleeve, tip portion, outer tube layer, and nut adapted to allow the inner tube layer to pass therethrough or extend over the inner layer. The ends of the tip portion and inner layer together can define a substantially flat surface which can form a seal in a flat-bottomed port of the manifold, block, or plate, which can be used in a component in an analytical instrument system, including for example a liquid chromatography system. The nut, tube, ferrule, and transfer tube or liner tube may comprise biocompatible materials. In addition, the nut may have a slot, such as a slot adapted to allow the tube and the nut to be easily and quickly separated or to allow a portion of the tube to be easily and quickly inserted in the nut.

Manifold connection assembly

A tubing or fitting assembly has an inner tube layer, an outer tube layer, a sleeve, a tip portion, and can have a nut. Each of the nut, sleeve, inner and outer tubing layers, and tip portion have a passageway therethrough, with at least the passageways in the sleeve, tip portion, outer tube layer, and nut adapted to allow the inner tube layer to pass therethrough or extend over the inner layer. The tip portion can be molded over an end portion of the inner tube layer and also over a portion of the sleeve. The sleeve may include a retention feature in the form of a lip which extends into the tip portion, and also a narrower portion so that the tip portion and sleeve remain coupled together. The inner and outer tubing layers can also be retained by an interference fit. The ends of the tip portion and inner layer together define a substantially flat surface which can form a seal in a flat-bottomed port of a component such as may be found in any one of a number of components in an analytical instrument system, including for example a liquid chromatography system. The nut, tube, ferrule, and transfer tube or liner tube may comprise biocompatible materials. In addition, the nut may have a slot, such as a slot adapted to allow the tube and the nut to be easily and quickly separated or to allow a portion of the tube to be easily and quickly inserted in the nut.

Face-sealing fluidic connection system

Fluidic connection assemblies, ports, unions and other components are provided that are well-suited for use in HPLC and UHPLC, as well as in other analytical instrument systems. Such assemblies, ports, unions and components can be biocompatible.

High pressure fluidic connection assemblies

A microfluidic interconnect system and method for assembly thereof is described. The microfluidic interconnect has a port and a seal, with the port having a reverse taper. The port has a first port end, a second port end, and an inner port surface with a tapered portion. Each port end has an opening with a diameter, and in certain embodiments, the diameter of the first port end is smaller than the diameter of the second port end. The seal has a first end and a second end, and each seal end has a rim and an opening with an inner diameter and an outer diameter. The seal also has an inner surface and an outer surface, where in certain embodiments, each surface has a tapered portion. In certain embodiments, the inner diameter of the first seal end is equal to or larger than the inner diameter of the second seal end, the outer diameter of the first seal end is equal to or smaller than the outer diameter of the second seal end, and the outer diameter of the second seal end is larger than the outer diameter of each port end. In certain embodiments, a tube is slidably coupled to the inner surface of the seal, and the tube has an outer diameter that is equal to or larger than the inner diameter of the second seal end.

Microfluidic interconnect

A fitting assembly having a nut, a ferrule, and a ferrule tip that may be assembled by an operator. The fitting assembly includes a nut with first and second ends, with the second end adapted to receive the first end of a ferrule, and a ferrule tip with a first end having an externally tapered portion adapted to abut the second end of the ferrule and a second end adapted to be received in a component or fitting of a liquid chromatography system. The nut, ferrule and ferrule tip of the fitting assembly have passageways therethrough for receiving and removably holding tubing.

Connection assembly for ultra high pressure liquid chromatography

This invention relates to an aerator that resides fully in the neck of a bottle or other liquid vessel. Through differential pressure, created through a venturi, the aerator mixes air with the fluid contained in the bottle. More specifically, the aerator can be used to mix air with wine as the bottle is inverted thus essentially instantly decanting the wine.

Aeration method

A fitting assembly is provided having a nut and a self-releasing ferrule, which in certain embodiments may be assembled by an operator. The nut and ferrule of the fitting assembly have passageways therethrough for receiving and removably holding tubing.

High pressure fitting with self-releasing ferrule

A fitting assembly having a single- or double-headed ferrule, a nut, and a fitting that may be assembled or dissembled by an operator. The fitting assembly includes a nut with first and second ends, with the second end adapted to receive or abut the first end of a ferrule, and further includes a fitting with a first end having an internally tapered portion adapted to receive the second end of the ferrule and a second end adapted to be removably connected to a component or fitting of a liquid chromatography system. The nut, ferrule and fitting of the fitting assembly have passageways therethrough for receiving and removably holding tubing.

A fitting assembly is provided having a nut and a self-releasing ferrule, which in certain embodiments may be assembled by an operator. The fitting assembly includes a nut with a first end, and a second end that defines a slot, and a ferrule with a first end that defines one or more slots, and a second end, with the second end of the nut adapted to receive the first end of the ferrule, the second end of the ferrule adapted to be received in a component or fitting of a liquid chromatography system. The nut and ferrule of the fitting assembly have passageways therethrough for receiving and removably holding tubing.

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Anacortes, WA, United States of America

Craig Graham