Mallinckrodt Hospital Products IP Limited

Mallinckrodt Pharmaceuticals Ireland Limited

Ino Therapeutics Gmbh

Ric Investments, Inc.

Craig Flanagan

Joseph Allen Orr

John Klaus

Thomas Kohlmann

Martin D Meglasson

Simon Freed

Manesh Naidu

Parag Shah

Jim Potenziano

Douglas Alan Greene

Jaron Matthew Acker

Craig R Tolmie

Frank Kenneth Schweighardt

David William Newman

Sarah Jayne Ridley

Lien-Lung Sheu

Muhammad Asif

Martin D Mcglasson

David Newman

The present invention generally relates to, amongst other things, systems, devices, materials, and methods that can improve the accuracy and/or precision of nitric oxide therapy by, for example, reducing the dilution of inhaled nitric oxide (NO). As described herein, NO dilution can occur because of various factors. To reduce the dilution of an intended NO dose, various exemplary nasal cannulas, pneumatic configurations, methods of manufacturing, and methods of use, etc. are disclosed.

Cannula for minimizing dilution of dosing during nitric oxide delivery

Described are systems and methods for administration of nitric oxide (NO) with use of left ventricular assists devices (LVADs), as well as systems and methods for monitoring the NO delivery devices and/or the LVAD.

Use and monitoring of inhaled nitric oxide with left ventricular assist devices

The principles and embodiments of the present invention relate to methods and systems for safely providing NO to a recipient for inhalation therapy. There are many potential safety issues that may arise from using a reactor cartridge that converts NOto NO, including exhaustion of consumable reactants of the cartridge reactor. Accordingly, various embodiments of the present invention provide systems and methods of determining the remaining useful life of a NO2-to-NO reactor cartridge and/or a break-through of NO, and providing an indication of the remaining useful life and/or break-through.

Systems and methods for indicating lifetime of an NO-to-NO reactor cartridge used to deliver NO for inhalation therapy to a patient

The present invention relates to a device and method of delivering inhaled Nitric Oxide (iNO) to a patient situated in a Magnetic Resonance Imaging (MRI) suite.

Gas delivery device and system for use in magnetic resonance imaging

Described are nasal cannulas that improve the precision of the delivered dose for nitric oxide therapy by reducing the dilution of nitric oxide. The nasal cannulas may reduce the total volume and potential for retrograde flow during nitric oxide therapy through the design of the specific dimensions of the flow path and/or having check valves in the nitric oxide delivery line and/or having a flapper or umbrella valve dedicated to nitric oxide delivery. The nasal cannulas may also use materials that limit oxygen diffusion through the cannula walls. The nosepiece for these cannulas may be manufactured by a molding technique.

Systems and methods for indicating lifetime of an NO2-to-NO reactor cartridge used to deliver NO for inhalation therapy to a patient

Growing community of inventors

Belmar, NJ, United States of America

Craig Flanagan