American Home Products Corporation

Wyeth

Other

Pfizer Corporation

Craig E Caufield

Amedeo A Failli

Alexander Greenfield

Timothy D Ocain

Katherine L Molnar-Kimber

John Anthony Butera

Guy A Schiehser

Robert J Steffan

Thomas Joseph Caggiano

Robert E McDevitt

Scott Christian Mayer

Alan Howard Katz

Eric Gould Gundersen

Joseph R Lennox

Lisa Marie Havran

John H Musser

Anthony F Kreft, Iii

Russell Graceffa

James M Rinker

Koi Morris

Schuyler Adam Antane

Alexander A Grinfeld

Nancie A Senko

Gregory F VonBurg

Alexander A Greenfield

Dominick Anthony Quagliato

Dennis Michael Kubrak

Surendra N Sehgal

Joseph Peter Sabatucci

Patrick Michael Andrae

John Francis Chiarello

Amadeo A Failli

Annmarie Enos

David C Hu

Eamonn P Morrison

Shaughnessy McGrath Naughton

Magid A Abou-Gharbia

Wenling Kao

Robert L Vogel

Russell F Graceffa

David Cheng Hu

Provided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin, for measuring levels of rapamycin or derivatives thereof; for isolating rapamycin binding proteins; and detecting antibodies specific for rapamycin or derivatives thereof. This invention also provides a rapamycin specific monoclonal antibody.

Rapamycin conjugates and antibodies

The present invention provides a compound of formula I and the use thereof for the inhibition of bacterial cell wall biosynthesis and for the therapeutic treatment of bacterial infection or disease in a patient in need thereof. The present invention also provides the use of the formula I compound for the control of ecto- or endoparasites in homeothermic animals. 

3-aryl-4-hydroxyfuranone compounds and the human and animal health use thereof

The present invention provides a compound of formula I and the use thereof for the inhibition of bacterial cell wall biosynthesis and for the therapeutic treatment of bacterial infection or disease in a patient in need thereof. The present invention also provides the use of the formula I compound for the control of ecto- or endoparasites in homeothermic animals 

Provided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin, for measuring levels of rapamycin or derivatives thereof; for isolating rapamycin binding proteins; and detecting antibodies specific for rapamycin or derivatives thereof. This invention also provides a rapamycin specific monclonal antibody.

Anti-rapamycin monoclonal antibodies

Rapamycin conjugates

This invention provides compounds of Formula I having the structureor a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.

2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia

This invention provides compounds of formula I, having the structurewherein R, R, A, and Z are as defined in the specification, or a pharmaceutically acceptable salt thereof, that are useful in treating metabolic disorders mediated by insulin resistance or hyperglycemia.

Substituted naphthylenes for the treatment of non-insulin dependent diabetes mellitus

This invention provides compounds of formula I, having the structurewherein R, R, R, R, A, and B are as defined in the specification, or a pharmaceutically acceptable salt thereof, that are useful in treating metabolic disorders mediated by insulin resistance or hyperglycemia.

Aryl substituted 3-ethoxy phenyl trifluoromethane sulfonamides for the treatment of non-insulin dependent diabetes mellitus (NIDDM)

Provided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin or a derivative thereof, for measuring levels of rapamycin or derivatives thereof; for isolating rapamycin binding proteins; and detecting antibodies specific for rapamycin or derivatives thereof. This invention also provides monoclonal antibodies specific for rapamycin or a ring opened derivative of rapamycin.

Monoclonal antibodies obtained using rapamycin position 27 conjugates as an immunogen

Rapamycin position 27 conjugates

This invention provides compounds of Formula I having the structure

This invention relates to compounds which possess immunosuppressive and/or anti tumor and/or antinflammatory activity in vivo and/or inhibit thymocyte proliferation in vitro. These compounds are therefore useful in the treaiment of transplantation rejection, autoimmune diseases such as lupus, rheumatoid ardiritis, diabetes mellitus, multiple sclerosis and in the treatment of Candida albicans infections and also in treatment of diseases of inflammation. These compounds are represented by the formula below ##STR1## wherein W and Y are OR.sup.1 and X and Z together form a bond or W and X are OR.sup.2 and Y and Z together form a bond, wherein:

Alkylated rapamycin derivatives

This invention provides compounds of formula I having the structure ##STR1## wherein R is (CH.sub.2).sub.n COOR.sup.4 ;

Pyranoindole and tetrahydrocarbazole inhibitors of COX-2

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Plainsboro, NJ, United States of America

Craig E Caufield